FEM1B
Gene Ontology Biological Process
- branching involved in prostate gland morphogenesis [IMP]
- epithelial cell maturation [IMP]
- epithelial cell maturation involved in prostate gland development [IMP]
- protein ubiquitination [IDA, ISO]
- regulation of DNA damage checkpoint [ISO]
- regulation of extrinsic apoptotic signaling pathway via death domain receptors [ISO]
- regulation of ubiquitin-protein transferase activity [ISO]
Gene Ontology Molecular Function
FNIP1
Gene Ontology Biological Process
- TOR signaling [ISO]
- cellular response to starvation [IMP]
- immature B cell differentiation [IMP]
- negative regulation of TOR signaling [IMP]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [IGI, IMP]
- negative regulation of transcription from RNA polymerase II promoter [ISO]
- positive regulation of B cell apoptotic process [IGI, IMP]
- positive regulation of GTPase activity [ISO]
- positive regulation of peptidyl-serine phosphorylation [ISO]
- positive regulation of protein phosphorylation [ISO]
- regulation of pro-B cell differentiation [IMP]
- regulation of protein phosphorylation [ISO]
Gene Ontology Molecular Function
Biochemical Activity (Ubiquitination)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
Structural basis and regulation of the reductive stress response.
Although oxidative phosphorylation is best known for producing ATP, it also yields reactive oxygen species (ROS) as invariant byproducts. Depletion of ROS below their physiological levels, a phenomenon known as reductive stress, impedes cellular signaling and has been linked to cancer, diabetes, and cardiomyopathy. Cells alleviate reductive stress by ubiquitylating and degrading the mitochondrial gatekeeper FNIP1, yet it is unknown ... [more]
Throughput
- Low Throughput
Additional Notes
- E2: UBE2R1
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| FEM1B FNIP1 | Co-crystal Structure Co-crystal Structure Interaction directly demonstrated at the atomic level by X-ray crystallography. Also used for NMR or Electron Microscopy (EM) structures. If there is no obvious bait-hit directionality to the interaction involving 3 or more proteins, then the co-crystallized proteins should be listed as a complex. | Low | - | BioGRID | - | |
| FNIP1 FEM1B | Protein-peptide Protein-peptide An interaction is detected between a protein and a peptide derived from an interaction partner. This includes phage display experiments. | Low | - | BioGRID | - |
Curated By
- BioGRID