Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

TRIM58 inactivates p53/p21 to promote chemoresistance via ubiquitination of DDX3 in breast cancer.

Wang J, Yang F, Zhuang J, Huo Q, Li J, Xie N

Chemotherapy resistance is that the most important reason behind of carcinoma treatment failure but the underlying molecular mechanisms are unclear. Members of the tripartite motifcontaining protein (TRIM) family play crucial roles in the carcinogenesis and development of resistance against chemotherapy. Herein, we first confirmed that TRIM58 is highly expressed in triple-negative breast cancer tissues and drug-resistant MCF7/ADR cells. Furthermore, TRIM58 ... [more]

Int J Biochem Cell Biol Dec. 01, 2021; 143();106140 [Pubmed: 34954155]

Throughput

  • Low Throughput

Curated By

  • BioGRID