BAIT
TRIB3
C20orf97, NIPK, SINK, SKIP3, TRB3, RP5-1103G7.7
tribbles pseudokinase 3
GO Process (20)
GO Function (6)
GO Component (4)
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- cellular lipid metabolic process [TAS]
- cellular response to insulin stimulus [ISS]
- epidermal growth factor receptor signaling pathway [TAS]
- fibroblast growth factor receptor signaling pathway [TAS]
- innate immune response [TAS]
- insulin receptor signaling pathway [TAS]
- intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [IDA]
- negative regulation of fat cell differentiation [ISS]
- negative regulation of fatty acid biosynthetic process [ISS]
- negative regulation of protein kinase activity [IDA]
- negative regulation of transcription, DNA-templated [IMP]
- neurotrophin TRK receptor signaling pathway [TAS]
- phosphatidylinositol-mediated signaling [TAS]
- positive regulation of protein binding [ISS]
- positive regulation of ubiquitin-protein transferase activity [ISS]
- regulation of MAP kinase activity [IDA]
- regulation of glucose transport [ISS]
- response to endoplasmic reticulum stress [IDA]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
MYH10
NMMHC-IIB, NMMHCB
myosin, heavy chain 10, non-muscle
GO Process (5)
GO Function (7)
GO Component (13)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
TRIB3?GSK-3? interaction promotes lung fibrosis and serves as a potential therapeutic target.
Pulmonary fibrosis (PF) is a chronic, progressive, fatal interstitial lung disease with limited available therapeutic strategies. We recently reported that the protein kinase glycogen synthase kinase-3? (GSK-3?) interacts with and inactivates the ubiquitin-editing enzyme A20 to suppress the degradation of the transcription factor CCAAT/enhancer-binding protein beta (C/EBP?) in alveolar macrophages (AMs), resulting in a profibrotic phenotype of AMs and promoting ... [more]
Acta Pharm Sin B Oct. 01, 2021; 11(10);3105-3119 [Pubmed: 34729304]
Throughput
- High Throughput
Curated By
- BioGRID