BAIT
RPRD1A
HsT3101, P15RS
regulation of nuclear pre-mRNA domain containing 1A
GO Process (1)
GO Function (0)
GO Component (1)
Gene Ontology Biological Process
Gene Ontology Cellular Component
Homo sapiens
PREY
ALB
ANALBA, FDAH, PRO0883, PRO0903, PRO1341, GIG20
albumin
GO Process (16)
GO Function (10)
GO Component (7)
Gene Ontology Biological Process
- bile acid and bile salt transport [TAS]
- bile acid metabolic process [TAS]
- blood coagulation [TAS]
- cellular response to starvation [IDA]
- hemolysis by symbiont of host erythrocytes [IDA]
- lipoprotein metabolic process [TAS]
- maintenance of mitochondrion location [IDA]
- negative regulation of apoptotic process [IDA]
- negative regulation of programmed cell death [NAS]
- platelet activation [TAS]
- platelet degranulation [TAS]
- retina homeostasis [IEP]
- small molecule metabolic process [TAS]
- sodium-independent organic anion transport [TAS]
- transmembrane transport [TAS]
- transport [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
RPRD1A stabilizes NRF2 and aggravates HCC progression through competing with p62 for TRIM21 binding.
NRF2 is the master transcriptional activator of cytoprotective genes and Kelch-like ECH-associated protein 1 (Keap1), a biosensor for electrophiles and oxidation, promotes NRF2 degradation in unstressed conditions. SQSTM1/p62, an oncogenic protein aberrantly accumulated in hepatocellular carcinoma (HCC), binds and sequestrates Keap1, leading to the prevention of NRF2 degradation. Here, we show that p15INK4b-related sequence/regulation of nuclear pre-mRNA domain-containing protein 1A ... [more]
Cell Death Dis Dec. 17, 2020; 13(1);6 [Pubmed: 34921137]
Throughput
- Low Throughput
Curated By
- BioGRID