MLXIPL
Gene Ontology Biological Process
- anatomical structure morphogenesis [TAS]
- cellular response to carbohydrate stimulus [IBA]
- energy reserve metabolic process [TAS]
- fatty acid homeostasis [ISS]
- glucose homeostasis [ISS]
- glucose mediated signaling pathway [ISS]
- intracellular signal transduction [TAS]
- negative regulation of cell cycle arrest [IMP]
- negative regulation of oxidative phosphorylation [IMP]
- negative regulation of peptidyl-serine phosphorylation [IMP]
- negative regulation of transcription, DNA-templated [ISS]
- positive regulation of cell proliferation [IMP]
- positive regulation of cellular metabolic process [TAS]
- positive regulation of fatty acid biosynthetic process [ISS]
- positive regulation of glycolytic process [IMP]
- positive regulation of lipid biosynthetic process [IMP]
- positive regulation of transcription from RNA polymerase II promoter [ISS]
- positive regulation of transcription, DNA-templated [ISS]
- regulation of energy homeostasis [ISS]
- regulation of fatty acid biosynthetic process [TAS]
- regulation of transcription from RNA polymerase II promoter [IBA]
- regulation of transcription, DNA-templated [NAS]
- small molecule metabolic process [TAS]
- triglyceride homeostasis [NAS]
Gene Ontology Molecular Function
XPO1
Gene Ontology Biological Process
- RNA metabolic process [TAS]
- gene expression [TAS]
- intracellular transport of virus [TAS]
- mRNA metabolic process [TAS]
- mitotic cell cycle [TAS]
- negative regulation of transforming growth factor beta receptor signaling pathway [TAS]
- protein export from nucleus [IMP]
- ribosomal large subunit export from nucleus [IMP]
- ribosomal small subunit export from nucleus [IMP]
- transforming growth factor beta receptor signaling pathway [TAS]
- viral life cycle [TAS]
- viral process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
High glucose mediates the ChREBP/p300 transcriptional complex to activate proapoptotic genes Puma and BAX and contributes to intervertebral disc degeneration.
Emerging evidence shows that obesity and type 2 diabetes (T2D) are associated with intervertebral disc degeneration (IDD). However, the underlying mechanisms are still obscure. Here, we found that serum glucose concentrations were significantly increased in T2D-IDD patients. Detection of molecular changes indicated that two glucose transporters (GLUTs), including GLUT1 and GLUT4, were hyperactivated in these IDD patients with obesity. Using ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| XPO1 MLXIPL | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | - | BioGRID | 1439950 |
Curated By
- BioGRID