BAIT
MLXIPL
CHREBP, MIO, MONDOB, WBSCR14, WS-bHLH, bHLHd14
MLX interacting protein-like
GO Process (24)
GO Function (6)
GO Component (5)
Gene Ontology Biological Process
- anatomical structure morphogenesis [TAS]
- cellular response to carbohydrate stimulus [IBA]
- energy reserve metabolic process [TAS]
- fatty acid homeostasis [ISS]
- glucose homeostasis [ISS]
- glucose mediated signaling pathway [ISS]
- intracellular signal transduction [TAS]
- negative regulation of cell cycle arrest [IMP]
- negative regulation of oxidative phosphorylation [IMP]
- negative regulation of peptidyl-serine phosphorylation [IMP]
- negative regulation of transcription, DNA-templated [ISS]
- positive regulation of cell proliferation [IMP]
- positive regulation of cellular metabolic process [TAS]
- positive regulation of fatty acid biosynthetic process [ISS]
- positive regulation of glycolytic process [IMP]
- positive regulation of lipid biosynthetic process [IMP]
- positive regulation of transcription from RNA polymerase II promoter [ISS]
- positive regulation of transcription, DNA-templated [ISS]
- regulation of energy homeostasis [ISS]
- regulation of fatty acid biosynthetic process [TAS]
- regulation of transcription from RNA polymerase II promoter [IBA]
- regulation of transcription, DNA-templated [NAS]
- small molecule metabolic process [TAS]
- triglyceride homeostasis [NAS]
Gene Ontology Molecular Function
Homo sapiens
PREY
CNTN2
AXT, FAME5, TAG-1, TAX, TAX1
contactin 2 (axonal)
GO Process (4)
GO Function (1)
GO Component (6)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
High glucose mediates the ChREBP/p300 transcriptional complex to activate proapoptotic genes Puma and BAX and contributes to intervertebral disc degeneration.
Emerging evidence shows that obesity and type 2 diabetes (T2D) are associated with intervertebral disc degeneration (IDD). However, the underlying mechanisms are still obscure. Here, we found that serum glucose concentrations were significantly increased in T2D-IDD patients. Detection of molecular changes indicated that two glucose transporters (GLUTs), including GLUT1 and GLUT4, were hyperactivated in these IDD patients with obesity. Using ... [more]
Bone Dec. 01, 2020; 153();116164 [Pubmed: 34461288]
Throughput
- Low Throughput
Curated By
- BioGRID