BAIT
UCHL5
CGI-70, INO80R, UCH-L5, UCH37, RP11-101E13.2
ubiquitin carboxyl-terminal hydrolase L5
GO Process (5)
GO Function (5)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
PREY
USP5
ISOT
ubiquitin specific peptidase 5 (isopeptidase T)
GO Process (2)
GO Function (4)
GO Component (1)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Branched ubiquitin chain binding and deubiquitination by UCH37 facilitate proteasome clearance of stress-induced inclusions.
UCH37, also known as UCHL5, is a highly conserved deubiquitinating enzyme (DUB) that associates with the 26S proteasome. Recently, it was reported that UCH37 activity is stimulated by branched ubiquitin (Ub) chain architectures. To understand how UCH37 achieves its unique debranching specificity, we performed biochemical and Nuclear Magnetic Resonance (NMR) structural analyses and found that UCH37 is activated by contacts ... [more]
Elife Dec. 11, 2020; 10(); [Pubmed: 34761751]
Throughput
- High Throughput
Curated By
- BioGRID