BAIT
TRAF3
AI528849, CAP-1, CD40bp, CRAF1, LAP1, T-BAM, amn
TNF receptor-associated factor 3
GO Process (7)
GO Function (5)
GO Component (2)
Gene Ontology Biological Process
- negative regulation of NF-kappaB transcription factor activity [IMP, ISO, TAS]
- regulation of cytokine production [IMP]
- regulation of defense response to virus [IMP]
- regulation of interferon-beta production [IMP]
- regulation of proteolysis [IDA, IMP, ISO]
- toll-like receptor signaling pathway [IMP]
- tumor necrosis factor-mediated signaling pathway [IMP, ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
CHMP4B
2010012F05Rik, C76846, Snf7-2, RP23-29D15.3
charged multivesicular body protein 4B
GO Process (8)
GO Function (2)
GO Component (6)
Gene Ontology Biological Process
- negative regulation of autophagic vacuole assembly [ISO]
- negative regulation of neuron death [ISO]
- positive regulation of viral release from host cell [ISO]
- posttranslational protein targeting to membrane [ISO]
- protein homooligomerization [ISO]
- regulation of viral process [ISO]
- ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway [ISO]
- viral budding via host ESCRT complex [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
DYRK1a mediates BAFF-induced noncanonical NF-?B activation to promote autoimmunity and B-cell leukemogenesis.
B-cell-activating factor (BAFF) mediates B-cell survival and, when deregulated, contributes to autoimmune diseases and B-cell malignancies. The mechanism connecting BAFF receptor (BAFFR) signal to downstream pathways and pathophysiological functions is not well understood. Here we identified DYRK1a as a kinase that responds to BAFF stimulation and mediates BAFF-induced B-cell survival. B-cell-specific DYRK1a deficiency causes peripheral B-cell reduction and ameliorates autoimmunity ... [more]
Blood Dec. 09, 2020; 138(23);2360-2371 [Pubmed: 34255829]
Throughput
- Low Throughput
Additional Notes
- BioID
Curated By
- BioGRID