BAIT
TRAF3
AI528849, CAP-1, CD40bp, CRAF1, LAP1, T-BAM, amn
TNF receptor-associated factor 3
GO Process (7)
GO Function (5)
GO Component (2)
Gene Ontology Biological Process
- negative regulation of NF-kappaB transcription factor activity [IMP, ISO, TAS]
- regulation of cytokine production [IMP]
- regulation of defense response to virus [IMP]
- regulation of interferon-beta production [IMP]
- regulation of proteolysis [IDA, IMP, ISO]
- toll-like receptor signaling pathway [IMP]
- tumor necrosis factor-mediated signaling pathway [IMP, ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
MSH2
AI788990
mutS homolog 2 (E. coli)
GO Process (30)
GO Function (27)
GO Component (6)
Gene Ontology Biological Process
- ATP catabolic process [IMP, ISO]
- B cell differentiation [IMP]
- B cell mediated immunity [IMP]
- DNA repair [IMP, ISO]
- cell cycle arrest [IMP]
- cellular response to DNA damage stimulus [IMP]
- determination of adult lifespan [IMP]
- double-strand break repair [IMP]
- germ cell development [IMP]
- in utero embryonic development [IGI]
- intra-S DNA damage checkpoint [IGI]
- intrinsic apoptotic signaling pathway in response to DNA damage [IMP]
- intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [IBA, IGI]
- isotype switching [IMP]
- maintenance of DNA repeat elements [IBA, ISO]
- male gonad development [IMP]
- meiotic gene conversion [IBA]
- meiotic mismatch repair [IBA]
- mismatch repair [IDA, IGI, IMP, ISO]
- negative regulation of DNA recombination [IMP, ISO]
- negative regulation of neuron apoptotic process [IMP]
- negative regulation of reciprocal meiotic recombination [IBA]
- oxidative phosphorylation [IMP]
- positive regulation of helicase activity [ISO]
- postreplication repair [IMP, ISO]
- response to UV-B [IMP]
- response to X-ray [IMP]
- somatic hypermutation of immunoglobulin genes [IGI, IMP]
- somatic recombination of immunoglobulin gene segments [IGI, IMP]
- somatic recombination of immunoglobulin genes involved in immune response [IGI]
Gene Ontology Molecular Function- ADP binding [ISO]
- ATP binding [ISO]
- ATPase activity [IMP, ISO]
- DNA binding [IMP, ISO]
- DNA-dependent ATPase activity [IBA]
- MutLalpha complex binding [ISO]
- Y-form DNA binding [IBA]
- centromeric DNA binding [IDA]
- damaged DNA binding [IMP]
- dinucleotide insertion or deletion binding [ISO]
- dinucleotide repeat insertion binding [ISO]
- double-strand/single-strand DNA junction binding [IBA]
- double-stranded DNA binding [ISO]
- enzyme binding [ISO]
- four-way junction DNA binding [IBA, ISO]
- guanine/thymine mispair binding [IDA, ISO]
- heteroduplex DNA loop binding [IBA]
- magnesium ion binding [ISO]
- mismatched DNA binding [IMP, ISO]
- oxidized purine DNA binding [ISO]
- protein C-terminus binding [ISO]
- protein homodimerization activity [ISO]
- protein kinase binding [ISO]
- single base insertion or deletion binding [IBA]
- single guanine insertion binding [ISO]
- single thymine insertion binding [ISO]
- single-stranded DNA binding [ISO]
- ADP binding [ISO]
- ATP binding [ISO]
- ATPase activity [IMP, ISO]
- DNA binding [IMP, ISO]
- DNA-dependent ATPase activity [IBA]
- MutLalpha complex binding [ISO]
- Y-form DNA binding [IBA]
- centromeric DNA binding [IDA]
- damaged DNA binding [IMP]
- dinucleotide insertion or deletion binding [ISO]
- dinucleotide repeat insertion binding [ISO]
- double-strand/single-strand DNA junction binding [IBA]
- double-stranded DNA binding [ISO]
- enzyme binding [ISO]
- four-way junction DNA binding [IBA, ISO]
- guanine/thymine mispair binding [IDA, ISO]
- heteroduplex DNA loop binding [IBA]
- magnesium ion binding [ISO]
- mismatched DNA binding [IMP, ISO]
- oxidized purine DNA binding [ISO]
- protein C-terminus binding [ISO]
- protein homodimerization activity [ISO]
- protein kinase binding [ISO]
- single base insertion or deletion binding [IBA]
- single guanine insertion binding [ISO]
- single thymine insertion binding [ISO]
- single-stranded DNA binding [ISO]
Gene Ontology Cellular Component
Mus musculus
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
DYRK1a mediates BAFF-induced noncanonical NF-?B activation to promote autoimmunity and B-cell leukemogenesis.
B-cell-activating factor (BAFF) mediates B-cell survival and, when deregulated, contributes to autoimmune diseases and B-cell malignancies. The mechanism connecting BAFF receptor (BAFFR) signal to downstream pathways and pathophysiological functions is not well understood. Here we identified DYRK1a as a kinase that responds to BAFF stimulation and mediates BAFF-induced B-cell survival. B-cell-specific DYRK1a deficiency causes peripheral B-cell reduction and ameliorates autoimmunity ... [more]
Blood Dec. 09, 2020; 138(23);2360-2371 [Pubmed: 34255829]
Throughput
- Low Throughput
Additional Notes
- BioID
Curated By
- BioGRID