BAIT
RECQL4
RECQ4
RecQ protein-like 4
GO Process (5)
GO Function (4)
GO Component (1)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
PREY
SFN
YWHAS
stratifin
GO Process (13)
GO Function (2)
GO Component (5)
Gene Ontology Biological Process
- apoptotic process [TAS]
- establishment of skin barrier [ISS]
- intrinsic apoptotic signaling pathway [TAS]
- intrinsic apoptotic signaling pathway in response to DNA damage [IDA]
- membrane organization [TAS]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [IDA]
- negative regulation of protein kinase activity [TAS]
- negative regulation of protein serine/threonine kinase activity [TAS]
- positive regulation of epidermal cell differentiation [ISS]
- positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway [TAS]
- regulation of epidermal cell division [ISS]
- release of cytochrome c from mitochondria [IDA]
- signal transduction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
UBE2O and USP7 co-regulate RECQL4 ubiquitinylation and homologous recombination-mediated DNA repair.
The human RecQ DNA helicase, RECQL4, plays a pivotal role in maintaining genomic stability by regulating the DNA double-strand breaks (DSBs) repair pathway, and is, thus, involved in the regulation of aging and cancer onset. However, the regulatory mechanisms of RECQL4, especially its post-translational modifications, have not been fully illustrated. Here, we report that the E2/E3 hybrid ubiquitin-conjugating enzyme, UBE2O, physically ... [more]
FASEB J Dec. 01, 2021; 36(1);e22112 [Pubmed: 34921745]
Throughput
- Low Throughput
Curated By
- BioGRID