BAIT
MDE4
SPBC6B1.04
monopolin-like complex subunit Mde4
GO Process (4)
GO Function (0)
GO Component (6)
Gene Ontology Biological Process
Gene Ontology Cellular Component
Schizosaccharomyces pombe (972h)
PREY
BUB1
SPCC1322.12c
mitotic spindle checkpoint kinase Bub1
GO Process (7)
GO Function (2)
GO Component (4)
Gene Ontology Biological Process
- attachment of mitotic spindle microtubules to kinetochore [IMP]
- cellular protein localization [IMP]
- histone H2A-S121 phosphorylation [IDA]
- meiotic sister chromatid cohesion, centromeric [IGI]
- mitotic spindle assembly checkpoint [IMP]
- protein localization to kinetochore [IMP]
- signal transduction involved in mitotic spindle assembly checkpoint [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Schizosaccharomyces pombe (972h)
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
Phosphorylation state defines discrete roles for monopolin in chromosome attachment and spindle elongation.
BACKGROUND: It is unknown how oscillations in Cdk1 activity drive the dramatic changes in chromosome and spindle dynamics that occur at the metaphase/anaphase transition. RESULTS: We show that the Schizosaccharomyces pombe monopolin complex has distinct functions in metaphase and anaphase that are determined by the phosphorylation state of its Mde4 subunit. When Cdk1 activity is high in metaphase, Mde4 is ... [more]
Curr. Biol. Jun. 23, 2009; 19(12);985-95 [Pubmed: 19523829]
Throughput
- Low Throughput
Ontology Terms
- phenotype: inviable (APO:0000112)
Curated By
- BioGRID