Synthetic Lethality

A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.

Publication

Phosphorylation state defines discrete roles for monopolin in chromosome attachment and spindle elongation.

Choi SH, Peli-Gulli MP, Mcleod I, Sarkeshik A, Yates JR, Simanis V, McCollum D

BACKGROUND: It is unknown how oscillations in Cdk1 activity drive the dramatic changes in chromosome and spindle dynamics that occur at the metaphase/anaphase transition. RESULTS: We show that the Schizosaccharomyces pombe monopolin complex has distinct functions in metaphase and anaphase that are determined by the phosphorylation state of its Mde4 subunit. When Cdk1 activity is high in metaphase, Mde4 is ... [more]

Curr. Biol. Jun. 23, 2009; 19(12);985-95 [Pubmed: 19523829]

Throughput

  • Low Throughput

Ontology Terms

  • phenotype: inviable (APO:0000112)

Curated By

  • BioGRID