ATG16L1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
IFT20
Gene Ontology Biological Process
- cardiac muscle cell differentiation [IMP]
- centrosome localization [IMP]
- cilium assembly [IMP, ISO]
- intraciliary transport [IBA, IC, IMP]
- kidney development [IMP]
- neural precursor cell proliferation [IMP]
- neurogenesis [IMP]
- opsin transport [IMP]
- photoreceptor cell outer segment organization [IMP]
- protein localization to Golgi apparatus [IBA, ISO]
- protein localization to cilium [IMP, ISO]
- regulation of autophagic vacuole assembly [IMP]
- regulation of canonical Wnt signaling pathway [IMP]
- regulation of cilium assembly [IMP]
- smoothened signaling pathway [IMP]
- visual learning [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Golgi apparatus [IDA]
- cell [IBA]
- centriole [IDA]
- centrosome [IDA, ISO]
- ciliary basal body [IDA]
- ciliary base [IDA]
- cilium [IBA, IDA]
- dendrite terminus [IDA]
- extracellular vesicular exosome [ISO]
- intracellular [IBA]
- intraciliary transport particle B [IDA]
- microtubule cytoskeleton [ISO]
- motile cilium [IDA]
- photoreceptor connecting cilium [IDA]
- photoreceptor outer segment [IDA]
- primary cilium [IDA]
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
The autophagy protein ATG16L1 cooperates with IFT20 and INPP5E to regulate the turnover of phosphoinositides at the primary cilium.
The primary cilium (PC) regulates signalization linked to external stress sensing. Previous works established a functional interplay between the PC and the autophagic machinery. When ciliogenesis is promoted by serum deprivation, the autophagy protein ATG16L1 and the ciliary protein IFT20 are co-transported to the PC. Here, we demonstrate that IFT20 and ATG16L1 are part of the same complex requiring the ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID