ANXA1
Gene Ontology Biological Process
- ATP catabolic process [ISO]
- DNA duplex unwinding [ISO]
- DNA rewinding [ISO]
- DNA strand renaturation [ISO]
- alpha-beta T cell differentiation [IMP]
- arachidonic acid secretion [IMP]
- cell surface receptor signaling pathway [ISO]
- cellular response to glucocorticoid stimulus [ISO]
- cellular response to hydrogen peroxide [ISO]
- insulin secretion [ISO]
- keratinocyte differentiation [ISO]
- negative regulation of interleukin-8 secretion [ISO]
- negative regulation of phospholipase A2 activity [ISO]
- negative regulation of protein secretion [ISO]
- neutrophil clearance [ISO]
- neutrophil homeostasis [IMP, ISO]
- peptide cross-linking [ISO]
- positive regulation of G1/S transition of mitotic cell cycle [IMP]
- positive regulation of apoptotic process [ISO]
- positive regulation of neutrophil apoptotic process [IMP]
- positive regulation of prostaglandin biosynthetic process [ISO]
- positive regulation of vesicle fusion [ISO]
- prolactin secretion [ISO]
- regulation of cell proliferation [IMP]
- signal transduction [IMP]
Gene Ontology Molecular Function- annealing helicase activity [ISO]
- calcium-dependent phospholipid binding [ISO]
- calcium-dependent protein binding [ISO]
- double-stranded DNA-dependent ATPase activity [ISO]
- helicase activity [ISO]
- phospholipase A2 inhibitor activity [ISO]
- phospholipid binding [ISO]
- protein binding [IPI]
- protein binding, bridging [ISO]
- protein homodimerization activity [ISO]
- single-stranded DNA binding [ISO]
- single-stranded RNA binding [ISO]
- structural molecule activity [ISO]
- annealing helicase activity [ISO]
- calcium-dependent phospholipid binding [ISO]
- calcium-dependent protein binding [ISO]
- double-stranded DNA-dependent ATPase activity [ISO]
- helicase activity [ISO]
- phospholipase A2 inhibitor activity [ISO]
- phospholipid binding [ISO]
- protein binding [IPI]
- protein binding, bridging [ISO]
- protein homodimerization activity [ISO]
- single-stranded DNA binding [ISO]
- single-stranded RNA binding [ISO]
- structural molecule activity [ISO]
Gene Ontology Cellular Component
NBR1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Annexin-A1 SUMOylation regulates microglial polarization after cerebral ischemia by modulating IKK? stability via selective autophagy.
Annexin-A1 (ANXA1) has recently been proposed to play a role in microglial activation after brain ischemia, but the underlying mechanism remains poorly understood. Here, we demonstrated that ANXA1 is modified by SUMOylation, and SUMOylated ANXA1 could promote the beneficial phenotype polarization of microglia. Mechanistically, SUMOylated ANXA1 suppressed nuclear factor ?B activation and the production of proinflammatory mediators. Further study revealed ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID