BAIT

GPR158

RP11-59G22.1
G protein-coupled receptor 158
GO Process (0)
GO Function (0)
GO Component (0)
Homo sapiens
PREY

GPR158

RP11-59G22.1
G protein-coupled receptor 158
GO Process (0)
GO Function (0)
GO Component (0)
Homo sapiens

Co-crystal Structure

Interaction directly demonstrated at the atomic level by X-ray crystallography. Also used for NMR or Electron Microscopy (EM) structures. If there is no obvious bait-hit directionality to the interaction involving 3 or more proteins, then the co-crystallized proteins should be listed as a complex.

Publication

Cryo-EM structure of human GPR158 receptor coupled to the RGS7-G?5 signaling complex.

Patil DN, Singh S, Laboute T, Strutzenberg TS, Qiu X, Wu D, Novick SJ, Robinson CV, Griffin PR, Hunt JF, Izard T, Singh AK, Martemyanov KA

GPR158 is an orphan G protein–coupled receptor (GPCR) highly expressed in the brain, where it controls synapse formation and function. GPR158 has also been implicated in depression, carcinogenesis, and cognition. However, the structural organization and signaling mechanisms of GPR158 are largely unknown. We used single-particle cryo–electron microscopy (cryo-EM) to determine the structures of human GPR158 alone and bound to an ... [more]

Science Jan. 07, 2022; 375(6576);86-91 [Pubmed: 34793198]

Throughput

  • Low Throughput

Additional Notes

  • CryoEM

Curated By

  • BioGRID