BAIT
HTR1A
5-HT-1A, 5-HT1A, 5HT1a, ADRB2RL1, ADRBRL1, G-21, PFMCD
5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled
GO Process (9)
GO Function (2)
GO Component (2)
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [IMP]
- adenylate cyclase-inhibiting serotonin receptor signaling pathway [IDA]
- behavioral fear response [ISS]
- exploration behavior [ISS]
- positive regulation of cell proliferation [TAS]
- regulation of dopamine metabolic process [ISS]
- regulation of serotonin secretion [ISS]
- serotonin metabolic process [ISS]
- serotonin receptor signaling pathway [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
PPP1CC
PP-1G, PP1C, PPP1G
protein phosphatase 1, catalytic subunit, gamma isozyme
GO Process (9)
GO Function (6)
GO Component (9)
Gene Ontology Biological Process
- circadian regulation of gene expression [ISS]
- entrainment of circadian clock by photoperiod [ISS]
- mitotic cell cycle [TAS]
- negative regulation of transforming growth factor beta receptor signaling pathway [TAS]
- protein dephosphorylation [IMP, ISS]
- regulation of circadian rhythm [IMP]
- small molecule metabolic process [TAS]
- transforming growth factor beta receptor signaling pathway [TAS]
- triglyceride catabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
HTR1A Inhibits the Progression of Triple-Negative Breast Cancer via TGF-? Canonical and Noncanonical Pathways.
Triple-negative breast cancer is the most aggressive subtype of breast cancer and the incidence of depression in breast cancer patients is high, which leading to worse survival and increased risk of recurrence. The effect of antidepressants on breast cancer patients remains contradictory, which might be due to variations in antidepression targets. Therefore, there is significant value to explore the antitumor ... [more]
Adv Sci (Weinh) Dec. 01, 2021; 9(12);e2105672 [Pubmed: 35199941]
Throughput
- High Throughput
Curated By
- BioGRID