BAIT
HTR1A
5-HT-1A, 5-HT1A, 5HT1a, ADRB2RL1, ADRBRL1, G-21, PFMCD
5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled
GO Process (9)
GO Function (2)
GO Component (2)
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [IMP]
- adenylate cyclase-inhibiting serotonin receptor signaling pathway [IDA]
- behavioral fear response [ISS]
- exploration behavior [ISS]
- positive regulation of cell proliferation [TAS]
- regulation of dopamine metabolic process [ISS]
- regulation of serotonin secretion [ISS]
- serotonin metabolic process [ISS]
- serotonin receptor signaling pathway [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
EEF1A1
CCS-3, CCS3, EE1A1, EEF-1, EEF1A, EF-Tu, EF1A, GRAF-1EF, HNGC:16303, LENG7, PTI1, eEF1A-1, RP11-505P4.2
eukaryotic translation elongation factor 1 alpha 1
GO Process (5)
GO Function (5)
GO Component (8)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
HTR1A Inhibits the Progression of Triple-Negative Breast Cancer via TGF-? Canonical and Noncanonical Pathways.
Triple-negative breast cancer is the most aggressive subtype of breast cancer and the incidence of depression in breast cancer patients is high, which leading to worse survival and increased risk of recurrence. The effect of antidepressants on breast cancer patients remains contradictory, which might be due to variations in antidepression targets. Therefore, there is significant value to explore the antitumor ... [more]
Adv Sci (Weinh) Dec. 01, 2021; 9(12);e2105672 [Pubmed: 35199941]
Throughput
- High Throughput
Curated By
- BioGRID