BAIT

PPP1R13L

IASPP, NKIP1, RAI, RAI4
protein phosphatase 1, regulatory subunit 13 like
Human Papilloma Virus (HPV) Project
GO Process (0)
GO Function (3)
GO Component (3)

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Homo sapiens
PREY

TMCO1

HP10122, PCIA3, PNAS-136, TMCC4, PNAS-10
transmembrane and coiled-coil domains 1
GO Process (0)
GO Function (0)
GO Component (1)

Gene Ontology Cellular Component

Homo sapiens

Affinity Capture-Western

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.

Publication

iASPP suppresses Gp78-mediated TMCO1 degradation to maintain Ca2+ homeostasis and control tumor growth and drug resistance.

Zheng S, Zhao D, Hou G, Zhao S, Zhang W, Wang X, Li L, Lin L, Tang TS, Hu Y

Ca2+ release from the endoplasmic reticulum (ER) is an essential event in the modulation of Ca2+ homeostasis, which is coordinated by multiple biological processes, ranging from cell proliferation to apoptosis. Deregulated Ca2+ homeostasis is linked with various cancer hallmarks; thus, uncovering the mechanisms underlying Ca2+ homeostasis dynamics may lead to new anticancer treatment strategies. Here, we demonstrate that a reported ... [more]

Proc Natl Acad Sci U S A Dec. 08, 2021; 119(6); [Pubmed: 35121659]

Throughput

  • Low Throughput

Curated By

  • BioGRID