BAIT
HMGA1
HMG-R, HMGA1A, HMGIY, RP11-513I15.2
high mobility group AT-hook 1
GO Process (16)
GO Function (11)
GO Component (6)
Gene Ontology Biological Process
- DNA catabolic process, endonucleolytic [IDA]
- DNA unwinding involved in DNA replication [NAS]
- base-excision repair [IDA]
- establishment of integrated proviral latency [TAS]
- negative regulation of cell proliferation [IMP]
- negative regulation of chromatin silencing [TAS]
- negative regulation of transcription, DNA-templated [IMP]
- nucleosome disassembly [TAS]
- oncogene-induced cell senescence [IDA]
- positive regulation of cellular senescence [IMP]
- positive regulation of transcription, DNA-templated [IMP]
- protein complex assembly [TAS]
- regulation of transcription, DNA-templated [TAS]
- response to virus [IEP]
- senescence-associated heterochromatin focus assembly [IDA]
- viral process [TAS]
Gene Ontology Molecular Function- 5'-deoxyribose-5-phosphate lyase activity [IDA]
- AT DNA binding [TAS]
- DNA binding [TAS]
- DNA-(apurinic or apyrimidinic site) lyase activity [IDA]
- enzyme binding [IPI]
- ligand-dependent nuclear receptor transcription coactivator activity [IMP]
- peroxisome proliferator activated receptor binding [IDA]
- protein binding [IPI]
- retinoic acid receptor binding [IDA]
- retinoid X receptor binding [IDA]
- transcription factor binding [IDA]
- 5'-deoxyribose-5-phosphate lyase activity [IDA]
- AT DNA binding [TAS]
- DNA binding [TAS]
- DNA-(apurinic or apyrimidinic site) lyase activity [IDA]
- enzyme binding [IPI]
- ligand-dependent nuclear receptor transcription coactivator activity [IMP]
- peroxisome proliferator activated receptor binding [IDA]
- protein binding [IPI]
- retinoic acid receptor binding [IDA]
- retinoid X receptor binding [IDA]
- transcription factor binding [IDA]
Gene Ontology Cellular Component
Homo sapiens
PREY
USP9X
DFFRX, FAF, FAM, MRX99, RP5-1172N10.4
ubiquitin specific peptidase 9, X-linked
GO Process (12)
GO Function (6)
GO Component (4)
Gene Ontology Biological Process
- BMP signaling pathway [IDA]
- axon extension [IMP]
- female gamete generation [TAS]
- gene expression [TAS]
- negative regulation of transcription from RNA polymerase II promoter [TAS]
- neuron migration [IMP]
- proteasome-mediated ubiquitin-dependent protein catabolic process [IBA]
- protein deubiquitination [IDA]
- regulation of proteasomal protein catabolic process [IBA]
- transcription initiation from RNA polymerase II promoter [TAS]
- transcription, DNA-templated [TAS]
- transforming growth factor beta receptor signaling pathway [IMP, TAS]
Gene Ontology Molecular Function
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
EZH2-CCF-cGAS Axis Promotes Breast Cancer Metastasis.
Cytoplasmic chromatin fragments (CCF) are recognized by the cytoplasmic DNA sensor cyclic GMP-AMP synthase (cGAS), which activates the cGAS-STING (cyclic GMP-AMP synthase-stimulator of interferon genes) pathway and promotes the production of inflammatory factors and breast cancer metastasis. However, the mechanisms by which CCF are formed in tumor cells and CCF activation cGAS promotes breast cancer metastasis remain unclear. Here, we ... [more]
Int J Mol Sci Feb. 04, 2022; 23(3); [Pubmed: 35163710]
Throughput
- Low Throughput
Curated By
- BioGRID