PELI1
Gene Ontology Biological Process
- negative regulation of NF-kappaB transcription factor activity [IMP]
- negative regulation of T cell activation [IMP]
- negative regulation of T cell proliferation [IMP]
- positive regulation of B cell activation [IMP]
- positive regulation of B cell proliferation [IMP]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IMP]
- positive regulation of cytokine production [IMP]
- positive regulation of protein ubiquitination [IMP]
- positive regulation of toll-like receptor 3 signaling pathway [IMP]
- positive regulation of toll-like receptor 4 signaling pathway [IMP]
- protein K48-linked ubiquitination [IDA]
- protein polyubiquitination [IMP]
- response to dsRNA [IMP]
- response to lipopolysaccharide [IMP]
Gene Ontology Molecular Function
PRKCQ
Gene Ontology Biological Process
- intracellular signal transduction [IMP, ISO]
- membrane protein ectodomain proteolysis [IDA]
- negative regulation of T cell apoptotic process [ISO]
- negative regulation of insulin receptor signaling pathway [ISO]
- positive regulation of NF-kappaB import into nucleus [ISO]
- positive regulation of NF-kappaB transcription factor activity [IMP, ISA, ISO]
- positive regulation of T cell activation [IMP]
- positive regulation of T cell proliferation [IMP]
- positive regulation of T-helper 17 type immune response [IMP]
- positive regulation of T-helper 2 cell activation [IMP]
- positive regulation of filopodium assembly [ISO]
- positive regulation of interleukin-17 production [IMP]
- positive regulation of interleukin-2 biosynthetic process [IMP]
- positive regulation of interleukin-4 production [IMP]
- positive regulation of protein secretion [ISO]
- positive regulation of stress fiber assembly [ISO]
- protein phosphorylation [IDA]
- regulation of G2/M transition of mitotic cell cycle [ISO]
- regulation of platelet aggregation [IMP]
- regulation of transcription, DNA-templated [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
The Pellino1-PKC? Signaling Axis Is an Essential Target for Improving Antitumor CD8+ T-lymphocyte Function.
CD8+ T cells play an important role in the elimination of tumors. However, the underlying mechanisms involved in eliciting and maintaining effector responses in CD8+ T cells remain to be elucidated. Pellino1 (Peli1) is a receptor signal-responsive ubiquitin E3 ligase, which acts as a critical mediator for innate immunity. Here, we found that the risk of developing tumors was dependent ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID