STAMBPL1
Gene Ontology Molecular Function
BIRC5
Gene Ontology Biological Process
- G2/M transition of mitotic cell cycle [IDA]
- cell division [IMP]
- cytokinesis [IMP]
- establishment of chromosome localization [IMP]
- inhibition of cysteine-type endopeptidase activity involved in apoptotic process [IBA]
- mitotic cell cycle [TAS]
- mitotic nuclear division [TAS]
- negative regulation of apoptotic process [IDA, IMP]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [IDA, IMP]
- negative regulation of transcription, DNA-templated [IMP]
- positive regulation of cell proliferation [TAS]
- positive regulation of exit from mitosis [IMP]
- positive regulation of mitotic cell cycle [IMP]
- protein complex localization [IMP]
- protein phosphorylation [IDA]
- protein ubiquitination [IBA]
- regulation of signal transduction [IBA]
- spindle assembly involved in mitosis [IBA]
- spindle checkpoint [IMP]
Gene Ontology Molecular Function- Ran GTPase binding [IPI]
- chaperone binding [IPI]
- cobalt ion binding [NAS]
- cofactor binding [IDA]
- cysteine-type endopeptidase inhibitor activity involved in apoptotic process [IMP]
- enzyme binding [IPI]
- identical protein binding [IPI]
- microtubule binding [IDA, TAS]
- protein binding [IPI]
- protein heterodimerization activity [IDA]
- protein homodimerization activity [IDA, IPI]
- tubulin binding [IDA]
- ubiquitin-protein transferase activity [IBA]
- zinc ion binding [IDA, NAS]
- Ran GTPase binding [IPI]
- chaperone binding [IPI]
- cobalt ion binding [NAS]
- cofactor binding [IDA]
- cysteine-type endopeptidase inhibitor activity involved in apoptotic process [IMP]
- enzyme binding [IPI]
- identical protein binding [IPI]
- microtubule binding [IDA, TAS]
- protein binding [IPI]
- protein heterodimerization activity [IDA]
- protein homodimerization activity [IDA, IPI]
- tubulin binding [IDA]
- ubiquitin-protein transferase activity [IBA]
- zinc ion binding [IDA, NAS]
Gene Ontology Cellular Component
- centriole [IDA]
- chromosome passenger complex [IPI]
- chromosome, centromeric region [IDA]
- condensed chromosome kinetochore [IDA]
- cytoplasm [IDA]
- cytoplasmic microtubule [IDA]
- cytosol [IDA, TAS]
- interphase microtubule organizing center [IDA]
- midbody [IDA]
- nuclear chromosome [IDA]
- nucleus [IDA]
- spindle microtubule [IDA]
Biochemical Activity (Deubiquitination)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
Helicobacter pylori-induced reactive oxygen species direct turnover of CSN-associated STAMBPL1 and augment apoptotic cell death.
Deubiquitinylases (DUBs) are central regulators of the ubiquitin system involved in protein regulation and cell signalling and are important for a variety of physiological processes. Most DUBs are cysteine proteases, and few other proteases are metalloproteases of the JAB1/MPN?+/MOV34 protease family (JAMM). STAM-binding protein like 1 (STAMBPL1), a member of the JAMM family, cleaves ubiquitin bonds and has a function ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| BIRC5 STAMBPL1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| BIRC5 STAMBPL1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID