BAIT

DIRAS2

Di-Ras2
DIRAS family, GTP-binding RAS-like 2
GO Process (1)
GO Function (1)
GO Component (1)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Homo sapiens
PREY

IGKV2-28

A19, IGKV228
immunoglobulin kappa variable 2-28
GO Process (0)
GO Function (0)
GO Component (0)
Homo sapiens

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

Diverse Ras-related GTPase DIRAS2, downregulated by PSMD2 in a proteasome-mediated way, inhibits colorectal cancer proliferation by blocking NF-?B signaling.

Ying K, Wang C, Liu S, Kuang Y, Tao Q, Hu X

Colorectal cancer (CRC) is the most common gastrointestinal cancer, with a high mortality rate but limited therapeutic targets. DIRAS family GTPase 2 (DIRAS2) is a member of the Ras-related small G-protein family whose biological functions and underlying mechanism in CRC remain poorly understood. In this study, we identified the crucial roles of DIRAS2 in CRC. DIRAS2 expression was downregulated in ... [more]

Int J Biol Sci Feb. 18, 2022; 18(3);1039-1050 [Pubmed: 35173535]

Throughput

  • Low Throughput

Curated By

  • BioGRID