ISW2
Gene Ontology Biological Process
- chromatin organization involved in regulation of transcription [IMP]
- chromatin remodeling [IDA, IMP]
- chromatin silencing at rDNA [IMP]
- chromatin silencing at telomere [IMP]
- negative regulation of antisense RNA transcription [IGI]
- negative regulation of transcription from RNA polymerase II promoter by pheromones [IMP]
- nucleosome positioning [IDA]
- termination of RNA polymerase II transcription [IGI]
Gene Ontology Molecular Function
NRG1
Gene Ontology Biological Process
- cellular hyperosmotic salinity response [IMP, IPI]
- negative regulation of cellular hyperosmotic salinity response by negative regulation of transcription from RNA polymerase II promoter [IGI]
- negative regulation of cellular response to alkaline pH by negative regulation of transcription from RNA polymerase II promoter [IMP, IPI]
- negative regulation of invasive growth in response to glucose limitation [IGI]
- negative regulation of invasive growth in response to glucose limitation by negative regulation of transcription from RNA polymerase II promoter [IGI]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- negative regulation of transcription from RNA polymerase II promoter by glucose [IGI, IMP]
- pseudohyphal growth [IGI]
- single-species surface biofilm formation [IMP]
Gene Ontology Molecular Function- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA, ISM]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IDA, IMP]
- RNA polymerase II repressing transcription factor binding [IPI]
- RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription [IGI]
- sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA, ISM]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IDA, IMP]
- RNA polymerase II repressing transcription factor binding [IPI]
- RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription [IGI]
- sequence-specific DNA binding [IDA]
Negative Genetic
Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores.
Publication
Investigation of RNA metabolism through large-scale genetic interaction profiling in yeast.
Gene deletion and gene expression alteration can lead to growth defects that are amplified or reduced when a second mutation is present in the same cells. We performed 154 genetic interaction mapping (GIM) screens with query mutants related with RNA metabolism and estimated the growth rates of about 700 000 double mutant Saccharomyces cerevisiae strains. The tested targets included the gene ... [more]
Throughput
- High Throughput
Ontology Terms
- phenotype: vegetative growth (APO:0000106)
Additional Notes
- 479 genetic interactions (GIs) were detected by both genetic interaction mapping (GIM) and SGA screens (adjusted log2(Q/R) score lower than -1 and SGA fitness score lower than -0.1).
- Supplementary table S6
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| NRG1 ISW2 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.136 | BioGRID | 365694 | |
| ISW2 NRG1 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.136 | BioGRID | 417421 | |
| ISW2 NRG1 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.137 | BioGRID | 2186863 |
Curated By
- BioGRID