BAIT

FBXO7

FBX, FBX07, FBX7, PARK15, PKPS, LL22NC03-28H9.2
F-box protein 7
Autophagy Project
Parkinson's Disease Project
UPS Project
Homo sapiens
PREY

TKT

HEL107, TK, TKT1
transketolase
Homo sapiens

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

A FBXO7/EYA2-SCFFBXW7 axis promotes AXL-mediated maintenance of mesenchymal and immune evasion phenotypes of cancer cells.

Shen JZ, Qiu Z, Wu Q, Zhang G, Harris R, Sun D, Rantala J, Barshop WD, Zhao L, Lv D, Won KA, Wohlschlegel J, Sangfelt O, Laman H, Rich JN, Spruck C

A mesenchymal tumor phenotype associates with immunotherapy resistance, although the mechanism is unclear. Here, we identified FBXO7 as a maintenance regulator of mesenchymal and immune evasion phenotypes of cancer cells. FBXO7 bound and stabilized SIX1 co-transcriptional regulator EYA2, stimulating mesenchymal gene expression and suppressing IFN?/?, chemokines CXCL9/10, and antigen presentation machinery, driven by AXL extracellular ligand GAS6. Ubiquitin ligase SCFFBXW7 ... [more]

Mol Cell Dec. 17, 2021; 82(6);1123-1139.e8 [Pubmed: 35182481]

Throughput

  • Low Throughput

Curated By

  • BioGRID