BAIT
DTX2
RNF58
deltex 2, E3 ubiquitin ligase
GO Process (0)
GO Function (1)
GO Component (2)
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
PFN1
ALS18
profilin 1
GO Process (10)
GO Function (6)
GO Component (5)
Gene Ontology Biological Process
- blood coagulation [TAS]
- negative regulation of actin filament bundle assembly [IMP]
- negative regulation of actin filament polymerization [IDA]
- negative regulation of stress fiber assembly [IMP]
- platelet activation [TAS]
- platelet degranulation [TAS]
- positive regulation of ATPase activity [IDA]
- positive regulation of actin filament polymerization [IGI]
- positive regulation of epithelial cell migration [IMP]
- positive regulation of ruffle assembly [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
An inducible CRISPR/Cas9 screen identifies DTX2 as a transcriptional regulator of human telomerase.
Most tumor cells reactivate telomerase to ensure unlimited proliferation, whereas the expression of human telomerase reverse transcriptase (hTERT) is tightly regulated and rate-limiting for telomerase activity maintenance. Several general transcription factors (TFs) have been found in regulating hTERT transcription; however, a systematic study is lacking. Here we performed an inducible CRISPR/Cas9 KO screen using an hTERT core promoter-driven reporter. We ... [more]
iScience Feb. 18, 2022; 25(2);103813 [Pubmed: 35198878]
Throughput
- Low Throughput
Additional Notes
- BioID
Curated By
- BioGRID