BAIT
DTX2
RNF58
deltex 2, E3 ubiquitin ligase
GO Process (0)
GO Function (1)
GO Component (2)
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
SENP1
SuPr-2
SUMO1/sentrin specific peptidase 1
GO Process (7)
GO Function (3)
GO Component (4)
Gene Ontology Biological Process
- activation of cysteine-type endopeptidase activity involved in apoptotic process [IMP]
- apoptotic signaling pathway [IMP]
- cellular protein metabolic process [TAS]
- positive regulation of transcription from RNA polymerase II promoter [IGI]
- post-translational protein modification [TAS]
- protein desumoylation [IMP]
- protein sumoylation [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
An inducible CRISPR/Cas9 screen identifies DTX2 as a transcriptional regulator of human telomerase.
Most tumor cells reactivate telomerase to ensure unlimited proliferation, whereas the expression of human telomerase reverse transcriptase (hTERT) is tightly regulated and rate-limiting for telomerase activity maintenance. Several general transcription factors (TFs) have been found in regulating hTERT transcription; however, a systematic study is lacking. Here we performed an inducible CRISPR/Cas9 KO screen using an hTERT core promoter-driven reporter. We ... [more]
iScience Feb. 18, 2022; 25(2);103813 [Pubmed: 35198878]
Throughput
- Low Throughput
Additional Notes
- BioID
Curated By
- BioGRID