BAIT
BCL10
CARMEN, CIPER, CLAP, IMD37, c-E10, mE10, RP11-234D19.2
B-cell CLL/lymphoma 10
GO Process (23)
GO Function (14)
GO Component (11)
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- T cell receptor signaling pathway [IDA, TAS]
- adaptive immune response [TAS]
- cell death [IDA]
- cellular response to mechanical stimulus [IEP]
- innate immune response [IEP, TAS]
- interleukin-6 biosynthetic process [NAS]
- lymphotoxin A biosynthetic process [NAS]
- negative regulation of mature B cell apoptotic process [IDA]
- neural tube closure [ISS]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IEP]
- positive regulation of NF-kappaB transcription factor activity [IDA]
- positive regulation of extrinsic apoptotic signaling pathway [IDA]
- positive regulation of interleukin-8 biosynthetic process [IMP]
- positive regulation of mast cell cytokine production [NAS]
- positive regulation of phosphorylation [IDA]
- positive regulation of protein ubiquitination [IDA]
- positive regulation of transcription, DNA-templated [IDA]
- protein homooligomerization [ISS, TAS]
- protein oligomerization [IPI]
- response to food [IDA]
- response to molecule of bacterial origin [IEP]
- toll-like receptor signaling pathway [IC]
Gene Ontology Molecular Function- NF-kappaB binding [IDA]
- enzyme binding [IPI]
- kinase activator activity [IDA]
- kinase binding [IPI]
- protease binding [IPI]
- protein C-terminus binding [IPI]
- protein binding [IPI]
- protein kinase B binding [IPI]
- protein kinase binding [IDA]
- protein self-association [IPI]
- transcription coactivator activity [IDA]
- transcription factor binding [IPI]
- ubiquitin binding [IDA]
- ubiquitin protein ligase binding [IPI]
- NF-kappaB binding [IDA]
- enzyme binding [IPI]
- kinase activator activity [IDA]
- kinase binding [IPI]
- protease binding [IPI]
- protein C-terminus binding [IPI]
- protein binding [IPI]
- protein kinase B binding [IPI]
- protein kinase binding [IDA]
- protein self-association [IPI]
- transcription coactivator activity [IDA]
- transcription factor binding [IPI]
- ubiquitin binding [IDA]
- ubiquitin protein ligase binding [IPI]
Gene Ontology Cellular Component
Homo sapiens
PREY
AIP
ARA9, FKBP16, FKBP37, SMTPHN, XAP-2, XAP2
aryl hydrocarbon receptor interacting protein
GO Process (4)
GO Function (6)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
A20 and ABIN-1 cooperate in balancing CBM complex-triggered NF-?B signaling in activated T cells.
T cell activation initiates protective adaptive immunity, but counterbalancing mechanisms are critical to prevent overshooting responses and to maintain immune homeostasis. The CARD11-BCL10-MALT1 (CBM) complex bridges T cell receptor engagement to NF-?B signaling and MALT1 protease activation. Here, we show that ABIN-1 is modulating the suppressive function of A20 in T cells. Using quantitative mass spectrometry, we identified ABIN-1 as ... [more]
Cell Mol Life Sci Jan. 31, 2022; 79(2);112 [Pubmed: 35099607]
Throughput
- High Throughput
Curated By
- BioGRID