BAIT
SMURF1
SMAD specific E3 ubiquitin protein ligase 1
GO Process (14)
GO Function (5)
GO Component (6)
Gene Ontology Biological Process
- BMP signaling pathway [IDA, TAS]
- cell differentiation [IDA]
- ectoderm development [TAS]
- negative regulation of BMP signaling pathway [TAS]
- negative regulation of transforming growth factor beta receptor signaling pathway [IDA, TAS]
- proteasome-mediated ubiquitin-dependent protein catabolic process [IDA]
- protein export from nucleus [IDA]
- protein localization to cell surface [IDA]
- protein polyubiquitination [IDA]
- protein ubiquitination [IDA]
- protein ubiquitination involved in ubiquitin-dependent protein catabolic process [IDA]
- receptor catabolic process [IDA]
- transforming growth factor beta receptor signaling pathway [TAS]
- ubiquitin-dependent SMAD protein catabolic process [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
LCP1
CP64, HEL-S-37, L-PLASTIN, LC64P, LPL, PLS2, RP11-139H14.1
lymphocyte cytosolic protein 1 (L-plastin)
GO Process (6)
GO Function (3)
GO Component (12)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Neddylation modification of the U3 snoRNA-binding protein RRP9 by Smurf1 promotes tumorigenesis.
Neddylation is a posttranslational modification that attaches ubiquitin-like protein Nedd8 to protein targets via Nedd8-specific E1-E2-E3 enzymes and modulates many important biological processes. Nedd8 attaches to a lysine residue of a substrate, not for degradation, but for modulation of substrate activity. We previously identified the HECT-type ubiquitin ligase Smurf1, which controls diverse cellular processes, is activated by Nedd8 through covalent ... [more]
J Biol Chem Dec. 01, 2020; 297(5);101307 [Pubmed: 34662580]
Quantitative Score
- 48.49 [Peptide ion score]
Throughput
- High Throughput
Additional Notes
- Affinity Capture-MS was carried out to identify high confidence protein-protein interactors with a Peptide ion score of greater than or equal to 20
Curated By
- BioGRID