PRMT1
Gene Ontology Biological Process
- cell surface receptor signaling pathway [TAS]
- histone H4-R3 methylation [IDA]
- histone methylation [IDA]
- negative regulation of megakaryocyte differentiation [IDA]
- neuron projection development [IMP]
- peptidyl-arginine methylation [IDA]
- peptidyl-arginine methylation, to asymmetrical-dimethyl arginine [IBA]
- protein methylation [TAS]
- regulation of transcription, DNA-templated [IBA]
Gene Ontology Molecular Function- N-methyltransferase activity [IDA, IMP]
- histone methyltransferase activity [IDA]
- histone methyltransferase activity (H4-R3 specific) [IDA]
- identical protein binding [IPI]
- methyltransferase activity [TAS]
- poly(A) RNA binding [IDA]
- protein binding [IPI]
- protein-arginine omega-N asymmetric methyltransferase activity [IBA]
- N-methyltransferase activity [IDA, IMP]
- histone methyltransferase activity [IDA]
- histone methyltransferase activity (H4-R3 specific) [IDA]
- identical protein binding [IPI]
- methyltransferase activity [TAS]
- poly(A) RNA binding [IDA]
- protein binding [IPI]
- protein-arginine omega-N asymmetric methyltransferase activity [IBA]
CARM1
Gene Ontology Biological Process
- cellular lipid metabolic process [TAS]
- histone H3-R17 methylation [ISS]
- histone H3-R2 methylation [IMP]
- histone methylation [IDA, ISS]
- peptidyl-arginine methylation, to asymmetrical-dimethyl arginine [IBA]
- positive regulation of fat cell differentiation [ISS]
- regulation of intracellular estrogen receptor signaling pathway [ISS]
- regulation of transcription, DNA-templated [IBA, ISS]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function- beta-catenin binding [TAS]
- histone methyltransferase activity [IDA]
- histone methyltransferase activity (H3-R17 specific) [ISS]
- histone-arginine N-methyltransferase activity [IBA]
- ligand-dependent nuclear receptor transcription coactivator activity [ISS]
- lysine-acetylated histone binding [ISS]
- protein binding [IPI]
- protein methyltransferase activity [ISS]
- protein-arginine N-methyltransferase activity [ISS]
- protein-arginine omega-N asymmetric methyltransferase activity [IBA, ISS]
- transcription coactivator activity [ISS]
- transcription regulatory region DNA binding [ISS]
- beta-catenin binding [TAS]
- histone methyltransferase activity [IDA]
- histone methyltransferase activity (H3-R17 specific) [ISS]
- histone-arginine N-methyltransferase activity [IBA]
- ligand-dependent nuclear receptor transcription coactivator activity [ISS]
- lysine-acetylated histone binding [ISS]
- protein binding [IPI]
- protein methyltransferase activity [ISS]
- protein-arginine N-methyltransferase activity [ISS]
- protein-arginine omega-N asymmetric methyltransferase activity [IBA, ISS]
- transcription coactivator activity [ISS]
- transcription regulatory region DNA binding [ISS]
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Arginine methylation and ubiquitylation crosstalk controls DNA end-resection and homologous recombination repair.
Cross-talk between distinct protein post-translational modifications is critical for an effective DNA damage response. Arginine methylation plays an important role in maintaining genome stability, but how this modification integrates with other enzymatic activities is largely unknown. Here, we identify the deubiquitylating enzyme USP11 as a previously uncharacterised PRMT1 substrate, and demonstrate that the methylation of USP11 promotes DNA end-resection and ... [more]
Throughput
- High Throughput
Additional Notes
- Affinity Capture-MS was carried out to identify high confidence protein-protein interactors
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| CARM1 PRMT1 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | 0.0016 | BioGRID | 3584920 | |
| PRMT1 CARM1 | Phenotypic Enhancement Phenotypic Enhancement A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | Low | - | BioGRID | - |
Curated By
- BioGRID