PLD2
Gene Ontology Biological Process
- Fc-gamma receptor signaling pathway involved in phagocytosis [TAS]
- cytoskeleton organization [TAS]
- glycerophospholipid biosynthetic process [TAS]
- innate immune response [TAS]
- phosphatidic acid biosynthetic process [TAS]
- phosphatidylglycerol biosynthetic process [TAS]
- phospholipid metabolic process [TAS]
- small GTPase mediated signal transduction [TAS]
- small molecule metabolic process [TAS]
- synaptic vesicle recycling [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
BAG5
Gene Ontology Biological Process
- negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [IDA]
- negative regulation of proteasomal ubiquitin-dependent protein catabolic process [IDA]
- negative regulation of protein refolding [ISS]
- negative regulation of protein ubiquitination [IMP, ISS]
- negative regulation of ubiquitin-protein transferase activity [ISS]
- neuron death [ISS]
- protein folding [TAS]
- regulation of inclusion body assembly [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Interactome Analysis of Human Phospholipase D and Phosphatidic Acid-Associated Protein Network.
Mammalian phospholipase D (PLD) enzyme family consists of six members. Among them, PLD1/2/6 catalyzes phosphatidic acid (PA) production, while PLD3/4/5 has no catalytic activities. Deregulation of the PLD-PA lipid signaling has been associated with various human diseases including cancer. However, a comprehensive analysis of the regulators and effectors for this crucial lipid metabolic pathway has not been fully achieved. Using ... [more]
Quantitative Score
- 1.0 [Saint Score]
Throughput
- High Throughput
Additional Notes
- Affinity capture MS was carried out to identify high confidence protein interactors with a SAINT score > 0.8 and raw spectra counts >2 (SAINT score reported here)
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| BAG5 PLD2 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.461 | BioGRID | 3242943 |
Curated By
- BioGRID