BAIT
PLD6
ZUC
phospholipase D family, member 6
GO Process (10)
GO Function (2)
GO Component (1)
Gene Ontology Biological Process
- DNA methylation involved in gamete generation [ISS]
- P granule organization [ISS]
- glycerophospholipid biosynthetic process [TAS]
- meiotic nuclear division [ISS]
- mitochondrial fusion [IMP]
- phosphatidylglycerol biosynthetic process [TAS]
- phospholipid metabolic process [TAS]
- piRNA metabolic process [ISS]
- small molecule metabolic process [TAS]
- spermatid development [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
ACSL1
ACS1, FACL1, FACL2, LACS, LACS1, LACS2
acyl-CoA synthetase long-chain family member 1
GO Process (10)
GO Function (1)
GO Component (4)
Gene Ontology Biological Process
- alpha-linolenic acid metabolic process [TAS]
- cellular lipid metabolic process [TAS]
- linoleic acid metabolic process [TAS]
- lipid biosynthetic process [IDA]
- long-chain fatty acid import [IDA]
- long-chain fatty acid metabolic process [IDA]
- long-chain fatty-acyl-CoA biosynthetic process [TAS]
- small molecule metabolic process [TAS]
- triglyceride biosynthetic process [TAS]
- unsaturated fatty acid metabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Interactome Analysis of Human Phospholipase D and Phosphatidic Acid-Associated Protein Network.
Mammalian phospholipase D (PLD) enzyme family consists of six members. Among them, PLD1/2/6 catalyzes phosphatidic acid (PA) production, while PLD3/4/5 has no catalytic activities. Deregulation of the PLD-PA lipid signaling has been associated with various human diseases including cancer. However, a comprehensive analysis of the regulators and effectors for this crucial lipid metabolic pathway has not been fully achieved. Using ... [more]
Mol Cell Proteomics Dec. 01, 2021; 21(2);100195 [Pubmed: 35007762]
Quantitative Score
- 1.0 [Saint Score]
Throughput
- High Throughput
Additional Notes
- Affinity capture MS was carried out to identify high confidence protein interactors with a SAINT score > 0.8 and raw spectra counts >2 (SAINT score reported here)
Curated By
- BioGRID