BAIT
MYCN
MODED, N-myc, NMYC, ODED, bHLHe37
v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog
GO Process (1)
GO Function (2)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
PREY
PRPS1
ARTS, CMTX5, DFN2, DFNX1, PPRibP, PRS-I, PRSI, RP11-540N4.1
phosphoribosyl pyrophosphate synthetase 1
GO Process (9)
GO Function (3)
GO Component (1)
Gene Ontology Biological Process
- 5-phosphoribose 1-diphosphate biosynthetic process [TAS]
- carbohydrate metabolic process [TAS]
- hypoxanthine biosynthetic process [IMP]
- nervous system development [IMP]
- purine nucleobase metabolic process [IMP]
- purine nucleotide biosynthetic process [IMP]
- pyrimidine nucleotide biosynthetic process [NAS]
- small molecule metabolic process [TAS]
- urate biosynthetic process [IMP]
Gene Ontology Molecular Function
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
EZH2 depletion potentiates MYC degradation inhibiting neuroblastoma and small cell carcinoma tumor formation.
Efforts to therapeutically target EZH2 have generally focused on inhibition of its methyltransferase activity, although it remains less clear whether this is the central mechanism whereby EZH2 promotes cancer. In the current study, we show that EZH2 directly interacts with both MYC family oncoproteins, MYC and MYCN, and promotes their stabilization in a methyltransferase-independent manner. By competing against the SCFFBW7 ... [more]
Nat Commun Dec. 10, 2021; 13(1);12 [Pubmed: 35013218]
Throughput
- High Throughput
Additional Notes
- Affinity Capture-MS was carried out to identify high confidence protein interactors with a p value<0.05 and a fold change >2 over control.
Curated By
- BioGRID