BAIT
MYC
MRTL, MYCC, bHLHe39, c-Myc
v-myc avian myelocytomatosis viral oncogene homolog
GO Process (39)
GO Function (9)
GO Component (4)
Gene Ontology Biological Process
- MAPK cascade [IMP]
- Notch signaling pathway [TAS]
- branching involved in ureteric bud morphogenesis [ISS]
- canonical Wnt signaling pathway [IDA]
- cell cycle arrest [IDA]
- cellular iron ion homeostasis [IDA]
- cellular response to DNA damage stimulus [IDA]
- cellular response to UV [IEP]
- cellular response to drug [IDA]
- chromatin remodeling [IDA]
- chromosome organization [IDA]
- energy reserve metabolic process [NAS]
- fibroblast apoptotic process [TAS]
- gene expression [TAS]
- negative regulation of apoptotic process [ISS]
- negative regulation of cell division [IDA]
- negative regulation of fibroblast proliferation [IDA]
- negative regulation of monocyte differentiation [IMP]
- negative regulation of stress-activated MAPK cascade [ISS]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- oxygen transport [NAS]
- positive regulation of DNA biosynthetic process [IMP]
- positive regulation of cell proliferation [IDA]
- positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [IDA]
- positive regulation of epithelial cell proliferation [IDA]
- positive regulation of fibroblast proliferation [IDA, IMP]
- positive regulation of mesenchymal cell proliferation [ISS]
- positive regulation of metanephric cap mesenchymal cell proliferation [ISS]
- positive regulation of response to DNA damage stimulus [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IMP, TAS]
- positive regulation of transcription, DNA-templated [IDA]
- regulation of gene expression [IDA]
- regulation of telomere maintenance [IMP]
- response to drug [IEP]
- response to gamma radiation [IDA]
- response to growth factor [TAS]
- transcription initiation from RNA polymerase II promoter [TAS]
- transcription, DNA-templated [TAS]
- transforming growth factor beta receptor signaling pathway [TAS]
Gene Ontology Molecular Function- DNA binding [ISS, TAS]
- E-box binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- protein binding [IPI]
- protein complex binding [IDA]
- repressing transcription factor binding [IPI]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription factor binding [IPI]
- DNA binding [ISS, TAS]
- E-box binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- protein binding [IPI]
- protein complex binding [IDA]
- repressing transcription factor binding [IPI]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription factor binding [IPI]
Gene Ontology Cellular Component
Homo sapiens
PREY
LYN
JTK8, p53Lyn, p56Lyn
LYN proto-oncogene, Src family tyrosine kinase
GO Process (58)
GO Function (7)
GO Component (9)
Gene Ontology Biological Process
- B cell homeostasis [ISS]
- Fc receptor mediated inhibitory signaling pathway [ISS]
- Fc receptor mediated stimulatory signaling pathway [IBA, ISS]
- Fc-epsilon receptor signaling pathway [TAS]
- Fc-gamma receptor signaling pathway involved in phagocytosis [TAS]
- JAK-STAT cascade involved in growth hormone signaling pathway [TAS]
- T cell costimulation [TAS]
- blood coagulation [TAS]
- cellular response to DNA damage stimulus [IDA]
- cellular response to peptide hormone stimulus [IBA]
- cellular response to retinoic acid [IMP]
- central nervous system development [IBA]
- dendritic cell differentiation [IBA, ISS]
- erythrocyte differentiation [ISS]
- immune response-regulating cell surface receptor signaling pathway [ISS, TAS]
- inflammatory response [IBA]
- innate immune response [IBA, TAS]
- leukocyte migration [TAS]
- lipopolysaccharide-mediated signaling pathway [ISS]
- negative regulation of B cell proliferation [IBA]
- negative regulation of ERK1 and ERK2 cascade [ISS]
- negative regulation of MAP kinase activity [ISS]
- negative regulation of cell proliferation [IMP]
- negative regulation of immune response [TAS]
- negative regulation of intracellular signal transduction [ISS]
- negative regulation of mast cell proliferation [IBA, ISS]
- negative regulation of protein phosphorylation [ISS]
- negative regulation of toll-like receptor 2 signaling pathway [ISS]
- negative regulation of toll-like receptor 4 signaling pathway [ISS]
- peptidyl-tyrosine autophosphorylation [IBA]
- peptidyl-tyrosine phosphorylation [IDA]
- platelet activation [TAS]
- platelet degranulation [IBA, ISS]
- positive regulation of cell proliferation [ISS]
- positive regulation of cellular component movement [IDA]
- positive regulation of dendritic cell apoptotic process [IBA, ISS]
- positive regulation of mast cell proliferation [IMP]
- positive regulation of neuron projection development [IMP]
- positive regulation of stress-activated protein kinase signaling cascade [IDA]
- positive regulation of tyrosine phosphorylation of STAT protein [ISS]
- protein autophosphorylation [IDA]
- protein phosphorylation [IDA]
- regulation of B cell apoptotic process [IBA]
- regulation of B cell receptor signaling pathway [IBA, ISS]
- regulation of ERK1 and ERK2 cascade [ISS]
- regulation of cell adhesion mediated by integrin [IMP]
- regulation of cytokine production [ISS]
- regulation of erythrocyte differentiation [ISS]
- regulation of mast cell activation [ISS]
- regulation of mast cell degranulation [IBA, ISS]
- regulation of monocyte chemotaxis [IMP]
- regulation of platelet aggregation [IBA, ISS]
- regulation of protein phosphorylation [TAS]
- response to hormone [ISS]
- signal transduction [TAS]
- signal transduction by phosphorylation [TAS]
- tolerance induction to self antigen [IBA, ISS, TAS]
- transmembrane receptor protein tyrosine kinase signaling pathway [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
EZH2 depletion potentiates MYC degradation inhibiting neuroblastoma and small cell carcinoma tumor formation.
Efforts to therapeutically target EZH2 have generally focused on inhibition of its methyltransferase activity, although it remains less clear whether this is the central mechanism whereby EZH2 promotes cancer. In the current study, we show that EZH2 directly interacts with both MYC family oncoproteins, MYC and MYCN, and promotes their stabilization in a methyltransferase-independent manner. By competing against the SCFFBW7 ... [more]
Nat Commun Dec. 10, 2021; 13(1);12 [Pubmed: 35013218]
Throughput
- High Throughput
Additional Notes
- Affinity Capture-MS was carried out to identify high confidence protein interactors with a p value<0.05 and a fold change >2 over control.
Curated By
- BioGRID