BAIT
PCBP1
HEL-S-85, HNRPE1, HNRPX, hnRNP-E1, hnRNP-X
poly(rC) binding protein 1
GO Process (3)
GO Function (4)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
EIF4A2
BM-010, DDX2B, EIF4A, EIF4F, eIF-4A-II, eIF4A-II
eukaryotic translation initiation factor 4A2
GO Process (12)
GO Function (4)
GO Component (3)
Gene Ontology Biological Process
- ATP catabolic process [IDA]
- RNA metabolic process [TAS]
- cellular protein metabolic process [TAS]
- cytokine-mediated signaling pathway [TAS]
- gene expression [TAS]
- mRNA metabolic process [TAS]
- negative regulation of RNA-directed RNA polymerase activity [IDA]
- nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [TAS]
- nuclear-transcribed mRNA poly(A) tail shortening [TAS]
- regulation of translational initiation [TAS]
- translation [TAS]
- translational initiation [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
The ubiquitin E3 ligase ARIH1 regulates hnRNP E1 protein stability, EMT and breast cancer progression.
The epithelial to mesenchymal transition (EMT), a process that is aberrantly activated in cancer and facilitates metastasis to distant organs, requires coordinated transcriptional and post-transcriptional control of gene expression. The tumor-suppressive RNA binding protein, hnRNP-E1, regulates splicing and translation of EMT-associated transcripts and it is thought that it plays a major role in the control of epithelial cell plasticity during ... [more]
Oncogene Dec. 01, 2021; 41(12);1679-1690 [Pubmed: 35102251]
Throughput
- High Throughput
Additional Notes
- miniTurbo BioID assay
Curated By
- BioGRID