BAIT
MTSS1
MIM, MIMA, MIMB
metastasis suppressor 1
GO Process (11)
GO Function (4)
GO Component (4)
Gene Ontology Biological Process
- actin cytoskeleton organization [TAS]
- cell adhesion [NAS]
- cellular component movement [NAS]
- cellular response to fluid shear stress [ISS]
- epithelial cell proliferation involved in renal tubule morphogenesis [ISS]
- glomerulus morphogenesis [ISS]
- microspike assembly [NAS]
- negative regulation of epithelial cell proliferation [ISS]
- nephron tubule epithelial cell differentiation [ISS]
- renal tubule morphogenesis [ISS]
- transmembrane receptor protein tyrosine kinase signaling pathway [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
SLC3A2
4F2, 4F2HC, 4T2HC, CD98, CD98HC, MDU1, NACAE
solute carrier family 3 (amino acid transporter heavy chain), member 2
GO Process (11)
GO Function (5)
GO Component (8)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
MTSS1 suppresses mammary tumor-initiating cells by enhancing RBCK1-mediated p65 ubiquitination.
Tumor-initiating cells (TICs) are considered the culprits of cancer development and progression. Dysregulation of metastasis suppressor protein 1 (MTSS1) has been widely observed in tumor metastasis, but its functional contribution and mechanism in cancer is poorly understood. Here we report a role of MTSS1 in suppressing TICs in breast cancer. Mtss1 knockout (KO) enhances the mammary epithelial TIC subpopulation in ... [more]
Nat Cancer Dec. 01, 2019; 1(2);222-234 [Pubmed: 35122005]
Throughput
- Low Throughput
Curated By
- BioGRID