BAIT
RPL11
DBA7, GIG34, L11, RP11-223J15.3
ribosomal protein L11
GO Process (17)
GO Function (4)
GO Component (5)
Gene Ontology Biological Process
- RNA metabolic process [TAS]
- SRP-dependent cotranslational protein targeting to membrane [TAS]
- cellular protein metabolic process [TAS]
- gene expression [TAS]
- mRNA metabolic process [TAS]
- nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [TAS]
- protein localization to nucleus [ISS]
- protein targeting [IMP]
- rRNA processing [IMP]
- ribosomal large subunit biogenesis [IMP]
- translation [NAS, TAS]
- translational elongation [TAS]
- translational initiation [TAS]
- translational termination [TAS]
- viral life cycle [TAS]
- viral process [TAS]
- viral transcription [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
PRDX3
AOP-1, AOP1, HBC189, MER5, PRO1748, SP-22, prx-III
peroxiredoxin 3
GO Process (15)
GO Function (7)
GO Component (7)
Gene Ontology Biological Process
- cellular response to oxidative stress [IDA]
- cellular response to reactive oxygen species [IMP]
- hydrogen peroxide catabolic process [IGI, IMP]
- mitochondrion organization [IMP]
- myeloid cell differentiation [ISS]
- negative regulation of apoptotic process [IDA, IMP]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [IMP]
- negative regulation of kinase activity [IDA]
- peptidyl-cysteine oxidation [IDA]
- positive regulation of NF-kappaB transcription factor activity [IDA]
- positive regulation of cell proliferation [IDA]
- regulation of mitochondrial membrane potential [IMP]
- response to hydrogen peroxide [IDA]
- response to lipopolysaccharide [ISS]
- response to oxidative stress [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Loss of RPS27a expression regulates the cell cycle, apoptosis, and proliferation via the RPL11-MDM2-p53 pathway in lung adenocarcinoma cells.
Depletion of certain ribosomal proteins induces p53 activation, which is mediated mainly by ribosomal protein L5 (RPL5) and/or ribosomal protein L11 (RPL11). Therefore, RPL5 and RPL11 may link RPs and p53 activation. Thus, this study aimed to explore whether RPs interact with RPL11 and regulate p53 activation in lung adenocarcinoma (LUAD) cells.The endogenous RPL11-binding proteins in A549 cells were pulled ... [more]
J Exp Clin Cancer Res Jan. 24, 2022; 41(1);33 [Pubmed: 35073964]
Throughput
- Low Throughput
Curated By
- BioGRID