BAIT
CREM
CREM-2, ICER, hCREM-2, RP11-324I22.1
cAMP responsive element modulator
GO Process (2)
GO Function (3)
GO Component (1)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
PREY
CD44
CDW44, CSPG8, ECMR-III, HCELL, HUTCH-I, IN, LHR, MC56, MDU2, MDU3, MIC4, Pgp1, AL133330.1
CD44 molecule (Indian blood group)
GO Process (25)
GO Function (5)
GO Component (8)
Gene Ontology Biological Process
- blood coagulation [TAS]
- carbohydrate metabolic process [TAS]
- cartilage development [IEP]
- cell-matrix adhesion [NAS]
- cellular response to fibroblast growth factor stimulus [IDA]
- cytokine-mediated signaling pathway [TAS]
- extracellular matrix disassembly [TAS]
- extracellular matrix organization [TAS]
- glycosaminoglycan metabolic process [TAS]
- hyaluronan catabolic process [IDA, TAS]
- hyaluronan metabolic process [TAS]
- interferon-gamma-mediated signaling pathway [TAS]
- leukocyte migration [TAS]
- monocyte aggregation [IMP]
- negative regulation of DNA damage response, signal transduction by p53 class mediator [IDA]
- negative regulation of apoptotic process [IMP]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [IMP]
- negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [IDA]
- positive regulation of ERK1 and ERK2 cascade [IDA]
- positive regulation of heterotypic cell-cell adhesion [IMP]
- positive regulation of monocyte aggregation [IMP]
- positive regulation of peptidyl-serine phosphorylation [IDA]
- positive regulation of peptidyl-tyrosine phosphorylation [IDA]
- single organismal cell-cell adhesion [NAS]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Evidence that the transcriptional repressor ICER is regulated via the N-end rule for ubiquitination.
ICER is a transcriptional repressor that is mono- or poly-ubiquitinated. This either causes ICER to be translocated from the nucleus, or degraded via the proteasome, respectively. In order to further studies the proteins involved in ICER regulation mass spectrometry analysis was performed to identify potential candidates. We identified twenty eight ICER-interacting proteins in human melanoma cells, Sk-Mel-24. In this study ... [more]
Exp Cell Res Dec. 01, 2021; 414(1);113083 [Pubmed: 35227662]
Throughput
- Low Throughput
Curated By
- BioGRID