BAIT
USP22
USP3L
ubiquitin specific peptidase 22
GO Process (10)
GO Function (8)
GO Component (2)
Gene Ontology Biological Process
- chromatin organization [TAS]
- embryo development [NAS]
- histone H4 acetylation [IDA]
- histone deubiquitination [IDA]
- histone ubiquitination [IDA]
- positive regulation of mitotic cell cycle [IMP]
- positive regulation of transcription, DNA-templated [IMP]
- proteasome-mediated ubiquitin-dependent protein catabolic process [IBA]
- protein deubiquitination [IDA]
- regulation of proteasomal protein catabolic process [IBA]
Gene Ontology Molecular Function- H4 histone acetyltransferase activity [IDA]
- cysteine-type endopeptidase activity [IBA]
- enzyme binding [IPI]
- ligand-dependent nuclear receptor transcription coactivator activity [IMP]
- protein binding [IPI]
- transcription coactivator activity [IDA]
- ubiquitin thiolesterase activity [IBA]
- ubiquitin-specific protease activity [IDA, IMP]
- H4 histone acetyltransferase activity [IDA]
- cysteine-type endopeptidase activity [IBA]
- enzyme binding [IPI]
- ligand-dependent nuclear receptor transcription coactivator activity [IMP]
- protein binding [IPI]
- transcription coactivator activity [IDA]
- ubiquitin thiolesterase activity [IBA]
- ubiquitin-specific protease activity [IDA, IMP]
Gene Ontology Cellular Component
Homo sapiens
PREY
DSP
DCWHKTA, DP, DPI, DPII
desmoplakin
GO Process (12)
GO Function (7)
GO Component (6)
Gene Ontology Biological Process
- apoptotic process [TAS]
- bundle of His cell to Purkinje myocyte communication [IMP]
- cellular component disassembly involved in execution phase of apoptosis [TAS]
- desmosome organization [ISS]
- epidermis development [TAS]
- intermediate filament organization [ISS]
- keratinocyte differentiation [IDA]
- peptide cross-linking [IDA]
- protein localization to adherens junction [ISS]
- regulation of heart rate by cardiac conduction [IMP]
- ventricular cardiac muscle cell action potential [IMP]
- ventricular compact myocardium morphogenesis [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
USP22 regulates lipidome accumulation by stabilizing PPAR? in hepatocellular carcinoma.
Elevated de novo lipogenesis is considered to be a crucial factor in hepatocellular carcinoma (HCC) development. Herein, we identify ubiquitin-specific protease 22 (USP22) as a key regulator for de novo fatty acid synthesis, which directly interacts with deubiquitinates and stabilizes peroxisome proliferator-activated receptor gamma (PPAR?) through K48-linked deubiquitination, and in turn, this stabilization increases acetyl-CoA carboxylase (ACC) and ATP citrate ... [more]
Nat Commun Dec. 21, 2021; 13(1);2187 [Pubmed: 35449157]
Throughput
- Low Throughput
Curated By
- BioGRID