USP14
Gene Ontology Biological Process
- negative regulation of ER-associated ubiquitin-dependent protein catabolic process [IMP]
- negative regulation of endopeptidase activity [IMP]
- proteasome-mediated ubiquitin-dependent protein catabolic process [IBA]
- protein deubiquitination [IDA]
- regulation of chemotaxis [IMP]
- regulation of proteasomal protein catabolic process [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
IL6
Gene Ontology Biological Process
- T-helper 17 cell lineage commitment [ISS]
- acute-phase response [TAS]
- cellular response to hydrogen peroxide [IDA]
- cellular response to lipopolysaccharide [IMP]
- cytokine-mediated signaling pathway [IDA]
- defense response to Gram-negative bacterium [IEP]
- defense response to Gram-positive bacterium [IEP]
- defense response to virus [IDA]
- endocrine pancreas development [ISS]
- glucagon secretion [ISS]
- hepatic immune response [IDA, TAS]
- humoral immune response [IC]
- inflammatory response [IDA]
- interleukin-6-mediated signaling pathway [IDA]
- monocyte chemotaxis [IC]
- negative regulation of apoptotic process [IDA]
- negative regulation of chemokine biosynthetic process [ISS]
- negative regulation of collagen biosynthetic process [IDA]
- negative regulation of fat cell differentiation [NAS]
- negative regulation of lipid storage [NAS]
- neuron projection development [IMP]
- neutrophil apoptotic process [IDA]
- neutrophil mediated immunity [IC]
- platelet activation [TAS]
- positive regulation of B cell activation [IDA]
- positive regulation of JAK-STAT cascade [IDA]
- positive regulation of MAPK cascade [IDA]
- positive regulation of NF-kappaB transcription factor activity [IDA]
- positive regulation of STAT protein import into nucleus [IC]
- positive regulation of T cell proliferation [IDA]
- positive regulation of acute inflammatory response [IDA]
- positive regulation of apoptotic process [IDA]
- positive regulation of cell proliferation [IDA, IMP]
- positive regulation of chemokine production [IDA, IMP]
- positive regulation of immunoglobulin secretion [IDA]
- positive regulation of interleukin-6 production [IDA]
- positive regulation of leukocyte chemotaxis [IC]
- positive regulation of osteoblast differentiation [TAS]
- positive regulation of peptidyl-serine phosphorylation [IDA]
- positive regulation of peptidyl-tyrosine phosphorylation [IDA]
- positive regulation of sequence-specific DNA binding transcription factor activity [IDA]
- positive regulation of smooth muscle cell proliferation [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of transcription, DNA-templated [IDA]
- positive regulation of translation [IDA]
- positive regulation of type B pancreatic cell apoptotic process [TAS]
- positive regulation of tyrosine phosphorylation of Stat3 protein [IDA]
- regulation of angiogenesis [IC]
- regulation of vascular endothelial growth factor production [IDA]
- response to glucocorticoid [IDA]
- response to peptidoglycan [IEP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Inhibition of USP14 suppresses ferroptosis and inflammation in LPS-induced goat mammary epithelial cells through ubiquitylating the IL-6 protein.
Ferroptosis, a novel manner of cell death depended on iron ion, contributed to goat mammary epithelial cell dysfunction. Interleukin-6 (IL-6) is a major pro-inflammatory factor during many inflammation-related diseases including mastitis, and a quite recently identified ferroptosis inducer. This study aims to explore the role of IL-6 in the dysfunction of goat mammary epithelial cells (GMECs) and how the level ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| IL6 USP14 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID