BAIT
PARK2
Park, Prkn
parkin RBR E3 ubiquitin protein ligase
GO Process (63)
GO Function (22)
GO Component (22)
Gene Ontology Biological Process
- adult locomotory behavior [ISO, ISS]
- aggresome assembly [ISO, ISS]
- cellular protein catabolic process [ISO]
- cellular protein modification process [TAS]
- cellular response to toxic substance [ISO, ISS]
- dopamine metabolic process [ISO]
- dopamine uptake involved in synaptic transmission [ISO]
- learning [ISO]
- locomotory behavior [ISO]
- mitochondrial fission [ISS]
- mitochondrion degradation [ISO, ISS]
- mitochondrion organization [ISS]
- negative regulation of JNK cascade [ISS]
- negative regulation of actin filament bundle assembly [ISO]
- negative regulation of cell death [ISO]
- negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [ISO, ISS]
- negative regulation of glucokinase activity [ISO, ISS]
- negative regulation of insulin secretion [ISO, ISS]
- negative regulation of mitochondrial fusion [ISS]
- negative regulation of neuron apoptotic process [ISO, ISS]
- negative regulation of neuron death [IGI, ISO]
- negative regulation of oxidative stress-induced neuron death [IGI]
- negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway [ISO, ISS]
- negative regulation of protein phosphorylation [ISO, ISS]
- negative regulation of reactive oxygen species metabolic process [ISO, ISS]
- negative regulation of release of cytochrome c from mitochondria [ISO, ISS]
- neuron cellular homeostasis [ISS]
- neuron maturation [IEP]
- norepinephrine metabolic process [ISO]
- positive regulation of DNA binding [ISO, ISS]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [ISO, ISS]
- positive regulation of mitochondrial fission [ISS]
- positive regulation of mitochondrial fusion [ISO, ISS]
- positive regulation of proteasomal protein catabolic process [ISO]
- positive regulation of protein linear polyubiquitination [ISO]
- positive regulation of transcription from RNA polymerase II promoter [ISO, ISS]
- positive regulation of tumor necrosis factor-mediated signaling pathway [ISO, ISS]
- proteasome-mediated ubiquitin-dependent protein catabolic process [ISO, ISS]
- protein K48-linked ubiquitination [ISO, ISS]
- protein K63-linked ubiquitination [ISO, ISS]
- protein autoubiquitination [ISO, ISS]
- protein localization to mitochondrion [ISS]
- protein metabolic process [ISO]
- protein monoubiquitination [ISO, ISS]
- protein polyubiquitination [ISO, ISS]
- protein ubiquitination [ISO, ISS]
- protein ubiquitination involved in ubiquitin-dependent protein catabolic process [ISO, ISS]
- regulation of autophagy [ISO, ISS]
- regulation of cellular response to oxidative stress [ISS]
- regulation of mitochondrion organization [ISO, ISS]
- regulation of neurotransmitter secretion [ISO]
- regulation of reactive oxygen species metabolic process [ISO]
- regulation of synaptic transmission [ISO]
- response to corticosterone [IEP]
- response to drug [IEP]
- response to endoplasmic reticulum stress [ISO]
- response to oxidative stress [ISS]
- response to unfolded protein [IDA]
- startle response [ISO]
- synaptic transmission, dopaminergic [ISO]
- synaptic transmission, glutamatergic [ISO]
- ubiquitin-dependent protein catabolic process [TAS]
- zinc ion homeostasis [ISS]
Gene Ontology Molecular Function- F-box domain binding [ISO, ISS]
- G-protein coupled receptor binding [ISO, ISS]
- Hsp70 protein binding [ISO, ISS]
- PDZ domain binding [ISO, ISS]
- actin binding [ISO]
- chaperone binding [ISO]
- cullin family protein binding [ISO, ISS]
- heat shock protein binding [ISO]
- histone deacetylase binding [ISO]
- identical protein binding [ISO, ISS]
- kinase binding [ISO]
- protein binding [IPI]
- protein complex binding [IDA]
- protein kinase binding [ISO, ISS]
- transcription regulatory region sequence-specific DNA binding [ISS]
- tubulin binding [ISO]
- ubiquitin binding [ISO, ISS]
- ubiquitin conjugating enzyme binding [ISO, ISS]
- ubiquitin protein ligase activity [ISO]
- ubiquitin protein ligase binding [ISO]
- ubiquitin-protein transferase activity [ISO, ISS, TAS]
- ubiquitin-specific protease binding [ISO]
- F-box domain binding [ISO, ISS]
- G-protein coupled receptor binding [ISO, ISS]
- Hsp70 protein binding [ISO, ISS]
- PDZ domain binding [ISO, ISS]
- actin binding [ISO]
- chaperone binding [ISO]
- cullin family protein binding [ISO, ISS]
- heat shock protein binding [ISO]
- histone deacetylase binding [ISO]
- identical protein binding [ISO, ISS]
- kinase binding [ISO]
- protein binding [IPI]
- protein complex binding [IDA]
- protein kinase binding [ISO, ISS]
- transcription regulatory region sequence-specific DNA binding [ISS]
- tubulin binding [ISO]
- ubiquitin binding [ISO, ISS]
- ubiquitin conjugating enzyme binding [ISO, ISS]
- ubiquitin protein ligase activity [ISO]
- ubiquitin protein ligase binding [ISO]
- ubiquitin-protein transferase activity [ISO, ISS, TAS]
- ubiquitin-specific protease binding [ISO]
Gene Ontology Cellular Component
- Golgi apparatus [ISO]
- Golgi membrane [IDA]
- LUBAC complex [ISO, ISS]
- Parkin-FBXW7-Cul1 ubiquitin ligase complex [ISO, ISS]
- SCF ubiquitin ligase complex [ISO]
- aggresome [ISO, ISS]
- cytoplasm [IDA, ISO, ISS]
- cytoplasmic vesicle [IDA]
- cytosol [ISO, ISS]
- endoplasmic reticulum [IDA, ISO]
- endoplasmic reticulum membrane [IDA]
- intracellular [IDA]
- membrane raft [IDA]
- mitochondrion [ISO, ISS]
- neuron projection [ISO]
- nucleus [ISO]
- perinuclear region of cytoplasm [ISO]
- postsynaptic density [IDA]
- protein complex [ISO]
- synapse [IDA]
- synaptic vesicle [IDA]
- ubiquitin ligase complex [ISO, ISS]
Rattus norvegicus
PREY
MFN1
hfzo1, hfzo2
mitofusin 1
GO Process (1)
GO Function (1)
GO Component (0)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
Biochemical Activity (Ubiquitination)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
Selective localization of Mfn2 near PINK1 enables its preferential ubiquitination by Parkin on mitochondria.
Mutations in Parkin and PINK1 cause early-onset familial Parkinson's disease. Parkin is a RING-In-Between-RING E3 ligase that transfers ubiquitin from an E2 enzyme to a substrate in two steps: (i) thioester intermediate formation on Parkin and (ii) acyl transfer to a substrate lysine. The process is triggered by PINK1, which phosphorylates ubiquitin on damaged mitochondria, which in turn recruits and ... [more]
Open Biol Dec. 01, 2021; 12(1);210255 [Pubmed: 35042405]
Throughput
- Low Throughput
Additional Notes
- E2: UbcH7
Curated By
- BioGRID