BAIT
AGO1
Ago, Ago-1, CG6671, Dm Ago1, DmAgo1, Dmel\CG6671, MRE20, ago1-1, anon-WO0257455.29, dAGO1, l(2)04845, l(2)4845, l(2)k00208, l(2)k08121, Dmel_CG6671
Argonaute-1
GO Process (16)
GO Function (4)
GO Component (6)
Gene Ontology Biological Process
- RNA interference [TAS]
- chromatin silencing [IMP]
- female germ-line stem cell maintenance [IMP]
- gene silencing by miRNA [IMP]
- germarium-derived female germ-line cyst formation [IMP]
- germarium-derived oocyte fate determination [IMP]
- habituation [IMP]
- mRNA catabolic process [IGI, IMP]
- mRNA cleavage involved in gene silencing by miRNA [IDA, IMP]
- negative regulation of translation [IMP]
- production of miRNAs involved in gene silencing by miRNA [IMP]
- production of siRNA involved in RNA interference [IMP]
- regulation of olfactory learning [IMP]
- segment polarity determination [IGI]
- synapse assembly [TAS]
- targeting of mRNA for destruction involved in RNA interference [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Drosophila melanogaster
PREY
SPI
CG10334, CT29014, Dmel\CG10334, EP(2)2378, Spitz, anon-WO0118547.158, l(2)01068, l(2)37Fa, l(2)s3547, s-spi, sSpi, Dmel_CG10334
spitz
GO Process (25)
GO Function (2)
GO Component (5)
Gene Ontology Biological Process
- G2/M transition of mitotic cell cycle [NAS]
- R8 cell-mediated photoreceptor organization [NAS]
- behavioral response to ethanol [IMP]
- border follicle cell migration [IMP]
- branched duct epithelial cell fate determination, open tracheal system [TAS]
- determination of genital disc primordium [IMP]
- epidermal growth factor receptor signaling pathway [NAS, TAS]
- epithelial cell proliferation involved in Malpighian tubule morphogenesis [IMP]
- heart process [IMP]
- imaginal disc-derived wing morphogenesis [IMP]
- negative regulation of apoptotic process [IMP, NAS]
- negative regulation of compound eye retinal cell programmed cell death [NAS]
- neurogenesis [IMP]
- oenocyte development [IGI, IMP]
- olfactory learning [IMP]
- open tracheal system development [TAS]
- peripheral nervous system development [IMP]
- positive regulation of cell proliferation [IMP]
- positive regulation of epidermal growth factor receptor signaling pathway [NAS]
- positive regulation of neurogenesis [IMP]
- salivary gland boundary specification [NAS]
- second mitotic wave involved in compound eye morphogenesis [NAS]
- spiracle morphogenesis, open tracheal system [IMP]
- stem cell fate commitment [IMP]
- stomatogastric nervous system development [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Drosophila melanogaster
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Lipid-mediated phase separation of AGO proteins on the ER controls nascent-peptide ubiquitination.
AGO/miRNA-mediated gene silencing and ubiquitin-mediated protein quality control represent two fundamental mechanisms that control proper gene expression. Here, we unexpectedly discover that fly and human AGO proteins, which are key components in the miRNA pathway, undergo lipid-mediated phase separation and condense into RNP granules on the endoplasmic reticulum (ER) membrane to control protein production. Phase separation on the ER is ... [more]
Mol Cell Dec. 07, 2021; 82(7);1313-1328.e8 [Pubmed: 35325613]
Throughput
- High Throughput
Curated By
- BioGRID