BAIT
USP49
RP11-298J23.4
ubiquitin specific peptidase 49
GO Process (5)
GO Function (5)
GO Component (0)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
PREY
HSPH1
HSP105, HSP105A, HSP105B, NY-CO-25, RP11-173P16.1
heat shock 105kDa/110kDa protein 1
GO Process (3)
GO Function (1)
GO Component (6)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
c-MYC-USP49-BAG2 axis promotes proliferation and chemoresistance of colorectal cancer cells in vitro.
Deubiquitinases (DUBs) play critical roles in tumorigenesis and are emerging as potential therapeutic targets. However, it remains less clear which DUBs may play important roles and represent a realistic vulnerability for a particular type of tumor. Here we revealed that Ubiquitin Specific Peptidase 49 (USP49) is transcriptionally activated by c-MYC in colorectal cancer (CRC), and CRC patients with elevated USP49 ... [more]
Biochem Biophys Res Commun Dec. 04, 2021; 607();117-123 [Pubmed: 35367823]
Throughput
- High Throughput
Curated By
- BioGRID