GATA1
Gene Ontology Biological Process
- basophil differentiation [IEP]
- blood coagulation [TAS]
- cellular response to thyroid hormone stimulus [IDA]
- eosinophil differentiation [IEP]
- eosinophil fate commitment [IDA]
- erythrocyte development [IMP]
- erythrocyte differentiation [IEP]
- male gonad development [IMP]
- megakaryocyte differentiation [IMP]
- negative regulation of apoptotic process [IMP]
- negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- negative regulation of transcription regulatory region DNA binding [IDA]
- platelet aggregation [IMP]
- platelet formation [IMP]
- positive regulation of erythrocyte differentiation [IMP]
- positive regulation of peptidyl-tyrosine phosphorylation [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- regulation of definitive erythrocyte differentiation [IDA]
- regulation of glycoprotein biosynthetic process [IMP]
- transcription from RNA polymerase II promoter [IDA]
- transcriptional activation by promoter-enhancer looping [ISS]
Gene Ontology Molecular Function- C2H2 zinc finger domain binding [IPI]
- DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IDA]
- RNA polymerase II regulatory region sequence-specific DNA binding [IDA]
- RNA polymerase II transcription factor binding [IPI]
- chromatin DNA binding [IDA]
- protein binding [IPI]
- sequence-specific DNA binding [IMP]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription regulatory region sequence-specific DNA binding [IMP]
- C2H2 zinc finger domain binding [IPI]
- DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IDA]
- RNA polymerase II regulatory region sequence-specific DNA binding [IDA]
- RNA polymerase II transcription factor binding [IPI]
- chromatin DNA binding [IDA]
- protein binding [IPI]
- sequence-specific DNA binding [IMP]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription regulatory region sequence-specific DNA binding [IMP]
Gene Ontology Cellular Component
SENP1
Gene Ontology Biological Process
- activation of cysteine-type endopeptidase activity involved in apoptotic process [IMP]
- apoptotic signaling pathway [IMP]
- cellular protein metabolic process [TAS]
- positive regulation of transcription from RNA polymerase II promoter [IGI]
- post-translational protein modification [TAS]
- protein desumoylation [IMP]
- protein sumoylation [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
SENP1 promotes triple-negative breast cancer invasion and metastasis via enhancing CSN5 transcription mediated by GATA1 deSUMOylation.
TNBC is characterized by high incidence of visceral metastasis and lacks effective clinical targets. This study aims to delineate the molecular mechanisms of SENP1 in TNBC invasion and metastasis. By using IHC to test the SENP1 expression in TNBC tissues, we analyzed the relationship between SENP1 expression and TNBC prognosis. We showed that SENP1 expression was higher in TNBC tumor ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID