An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

TPI1 activates the PI3K/AKT/mTOR signaling pathway to induce breast cancer progression by stabilizing CDCA5.

Jin X, Wang D, Lei M, Guo Y, Cui Y, Chen F, Sun W, Chen X

Triosephosphate isomerase 1 (TPI1), as a key glycolytic enzyme, is upregulated in multiple cancers. However, expression profile and regulatory mechanism of TPI1 in breast cancer (BRCA) remain mysterious.Western blotting and immunohistochemistry (IHC) assays were used to investigate the expression of TPI1 in BRCA specimens and cell lines. TPI1 correlation with the clinicopathological characteristics and prognosis of 362 BRCA patients was ... [more]

J Transl Med Dec. 04, 2021; 20(1);191 [Pubmed: 35509067]

Throughput

Low Throughput

Curated By

BioGRID

Interaction Summary

TPI1

Gene Ontology Biological Process

Gene Ontology Molecular Function

protein binding [IPI]triose-phosphate isomerase activity [EXP, NAS, TAS]

Gene Ontology Cellular Component

KRT6C