BAIT
WIPI1
ATG18, ATG18A, WIPI49
WD repeat domain, phosphoinositide interacting 1
GO Process (11)
GO Function (5)
GO Component (9)
Gene Ontology Biological Process
- activation of signaling protein activity involved in unfolded protein response [TAS]
- autophagic vacuole assembly [IBA]
- autophagy [IEP]
- cellular protein metabolic process [TAS]
- cellular response to nitrogen starvation [IBA]
- endoplasmic reticulum unfolded protein response [TAS]
- mitochondrion degradation [IBA]
- nucleophagy [IBA]
- protein lipidation [IBA]
- protein localization to pre-autophagosomal structure [IBA]
- vesicle targeting, trans-Golgi to endosome [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
VPS35
MEM3, PARK17, TCCCTA00141
vacuolar protein sorting 35 homolog (S. cerevisiae)
GO Process (5)
GO Function (2)
GO Component (7)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Co-localization
Interaction inferred from two proteins that co-localize in the cell by indirect immunofluorescence only when in addition, if one gene is deleted, the other protein becomes mis-localized. Also includes co-dependent association of proteins with promoter DNA in chromatin immunoprecipitation experiments.
Publication
CROP: a retromer-PROPPIN complex mediating membrane fission in the endo-lysosomal system.
Endo-lysosomal compartments exchange proteins by fusing, fissioning, and through endosomal transport carriers. Thereby, they sort many plasma membrane receptors and transporters and control cellular signaling and metabolism. How the membrane fission events are catalyzed is poorly understood. Here, we identify the novel CROP complex as a factor acting at this step. CROP joins members of two protein families: the peripheral ... [more]
EMBO J May. 16, 2022; 41(10);e109646 [Pubmed: 35466426]
Throughput
- Low Throughput
Curated By
- BioGRID