BAIT
SQSTM1
A170, OSF-6, Osi, STAP, STONE14, p62, RP23-319B15.3
sequestosome 1
GO Process (7)
GO Function (9)
GO Component (8)
Gene Ontology Biological Process
- autophagy [ISO]
- positive regulation of macroautophagy [IBA, ISO]
- positive regulation of protein phosphorylation [ISO]
- protein heterooligomerization [ISO]
- regulation of I-kappaB kinase/NF-kappaB signaling [ISO]
- regulation of nucleic acid-templated transcription [TAS]
- ubiquitin-dependent protein catabolic process [IBA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
YWHAH
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide
GO Process (11)
GO Function (8)
GO Component (4)
Gene Ontology Biological Process
- cytoskeleton organization [NAS]
- glucocorticoid catabolic process [ISO]
- glucocorticoid receptor signaling pathway [ISO]
- intracellular protein transport [IDA]
- membrane depolarization during action potential [ISO, ISS]
- negative regulation of apoptotic process [NAS]
- negative regulation of dendrite morphogenesis [IDA]
- positive regulation of transcription, DNA-templated [ISO]
- regulation of mitosis [NAS]
- regulation of sodium ion transmembrane transporter activity [ISO, ISS]
- regulation of sodium ion transport [ISO, ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Protective function of the SQSTM1/p62-NEDD4 complex against methylmercury toxicity.
SQSTM1/p62, hereinafter referred to as p62, is a stress-induced cellular protein that interacts with various signaling proteins as well as ubiquitinated proteins to regulate a variety of cellular functions and cell survival. Methylmercury (MeHg) exposure increases the levels of p62, the latter playing a protective role in MeHg-induced toxicity. However, the underlying mechanism by which p62 alleviates MeHg toxicity remains ... [more]
Biochem Biophys Res Commun Dec. 18, 2021; 609();134-140 [Pubmed: 35452957]
Throughput
- Low Throughput
Curated By
- BioGRID