BAIT
GJA1
AVSD3, CMDR, CX43, GJAL, HLHS1, HSS, ODDD
gap junction protein, alpha 1, 43kDa
GO Process (11)
GO Function (4)
GO Component (11)
Gene Ontology Biological Process
- atrial cardiac muscle cell action potential [TAS]
- cell communication by electrical coupling [IDA]
- cell-cell signaling [TAS]
- gap junction assembly [TAS]
- heart development [TAS]
- ion transmembrane transport [TAS]
- membrane organization [TAS]
- muscle contraction [TAS]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IMP]
- signal transduction [IMP]
- transport [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Golgi apparatus [ISS]
- Golgi membrane [TAS]
- Golgi-associated vesicle membrane [TAS]
- endoplasmic reticulum membrane [TAS]
- extracellular vesicular exosome [IDA]
- focal adhesion [IDA]
- gap junction [IDA, ISS]
- integral component of plasma membrane [TAS]
- intercalated disc [IDA, ISS]
- membrane raft [ISS]
- plasma membrane [ISS, TAS]
Homo sapiens
PREY
GSTP1
DFN7, FAEES3, GST3, GSTP, HEL-S-22, PI
glutathione S-transferase pi 1
GO Process (30)
GO Function (7)
GO Component (9)
Gene Ontology Biological Process
- cellular response to lipopolysaccharide [ISS]
- central nervous system development [TAS]
- common myeloid progenitor cell proliferation [ISS]
- glutathione derivative biosynthetic process [TAS]
- glutathione metabolic process [IDA]
- negative regulation of ERK1 and ERK2 cascade [IDA]
- negative regulation of I-kappaB kinase/NF-kappaB signaling [ISS]
- negative regulation of JUN kinase activity [IDA]
- negative regulation of MAP kinase activity [IDA]
- negative regulation of MAPK cascade [NAS]
- negative regulation of acute inflammatory response [NAS]
- negative regulation of apoptotic process [TAS]
- negative regulation of biosynthetic process [IDA]
- negative regulation of extrinsic apoptotic signaling pathway [IDA]
- negative regulation of fibroblast proliferation [ISS]
- negative regulation of interleukin-1 beta production [IDA]
- negative regulation of leukocyte proliferation [ISS]
- negative regulation of monocyte chemotactic protein-1 production [IDA]
- negative regulation of nitric-oxide synthase biosynthetic process [IDA]
- negative regulation of protein kinase activity [IDA]
- negative regulation of stress-activated MAPK cascade [ISS]
- negative regulation of tumor necrosis factor production [IDA]
- negative regulation of tumor necrosis factor-mediated signaling pathway [IC]
- nitric oxide storage [NAS]
- positive regulation of superoxide anion generation [ISS]
- regulation of ERK1 and ERK2 cascade [ISS]
- regulation of stress-activated MAPK cascade [ISS]
- response to reactive oxygen species [ISS]
- small molecule metabolic process [TAS]
- xenobiotic metabolic process [IDA, TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
The Effect of the NF?B-USP9X-Cx43 Axis on the Dynamic Balance of Bone Formation/Degradation during Ossification of the Posterior Longitudinal Ligament of the Cervical Spine.
Connexin 43- (Cx43-) mediated nuclear factor kappa-light-chain-enhancer of activated B cell (NF-?B) signaling has been found involved in the ossification of the posterior longitudinal ligament (OPLL). However, the underlying mechanism how OPLL is regulated has not been elucidated. In the present study, primary ligament fibroblast were isolated; immunoprecipitation (IP) and liquid chromatography-mass spectrometry (LC-MS) assays were applied to identify potential ... [more]
Oxid Med Cell Longev Apr. 09, 2022; 2022();1604932 [Pubmed: 35391932]
Throughput
- Low Throughput
Curated By
- BioGRID