BAIT
NSFL1C
P47, UBX1, UBXD10, UBXN2C, dJ776F14.1, RP4-776F14.2
NSFL1 (p97) cofactor (p47)
GO Process (6)
GO Function (3)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
SPTAN1
EIEE5, NEAS, SPTA2
spectrin, alpha, non-erythrocytic 1
GO Process (3)
GO Function (2)
GO Component (7)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Active conformation of the p97-p47 unfoldase complex.
The p97 AAA+ATPase is an essential and abundant regulator of protein homeostasis that plays a central role in unfolding ubiquitylated substrates. Here we report two cryo-EM structures of human p97 in complex with its p47 adaptor. One of the conformations is six-fold symmetric, corresponds to previously reported structures of p97, and lacks bound substrate. The other structure adopts a helical ... [more]
Nat Commun Dec. 12, 2021; 13(1);2640 [Pubmed: 35552390]
Throughput
- High Throughput
Curated By
- BioGRID