BAIT
TMEM173
2610307O08Rik, ERIS, MPYS, Mita, STING
transmembrane protein 173
GO Process (11)
GO Function (8)
GO Component (6)
Gene Ontology Biological Process
- activation of innate immune response [IMP, ISO]
- cellular response to exogenous dsRNA [ISO]
- cellular response to interferon-beta [IMP]
- defense response to virus [IMP, ISO]
- innate immune response [IMP, ISO]
- interferon-beta production [IMP, ISO]
- positive regulation of defense response to virus by host [ISO]
- positive regulation of protein binding [ISO]
- positive regulation of protein import into nucleus, translocation [ISO]
- positive regulation of transcription factor import into nucleus [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IDA, ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
CD44
AU023126, AW121933, AW146109, HERMES, Ly-24, Pgp-1, RP23-203N8.3
CD44 antigen
GO Process (25)
GO Function (8)
GO Component (12)
Gene Ontology Biological Process
- Wnt signaling pathway [IDA]
- branching involved in prostate gland morphogenesis [IMP]
- branching involved in ureteric bud morphogenesis [IMP]
- cell adhesion [IDA, ISO]
- cell migration [ISO]
- cellular response to fibroblast growth factor stimulus [ISO]
- hyaluronan catabolic process [ISO]
- macrophage fusion [ISO]
- monocyte aggregation [ISO]
- negative regulation of DNA damage response, signal transduction by p53 class mediator [IMP, ISO]
- negative regulation of apoptotic process [ISO]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [ISO]
- negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [IMP, ISO]
- negative regulation of mature B cell apoptotic process [IDA]
- neuron projection development [ISO]
- positive regulation of ERK1 and ERK2 cascade [IMP, ISO]
- positive regulation of adaptive immune response [NAS]
- positive regulation of gene expression [IGI]
- positive regulation of heterotypic cell-cell adhesion [ISO]
- positive regulation of monocyte aggregation [ISO]
- positive regulation of neutrophil apoptotic process [ISO]
- positive regulation of peptidyl-serine phosphorylation [IMP, ISO]
- positive regulation of peptidyl-tyrosine phosphorylation [IMP, ISO]
- regulation of cell growth [ISO]
- wound healing involved in inflammatory response [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Golgi apparatus [ISO]
- apical plasma membrane [ISO]
- basolateral plasma membrane [IDA, ISO]
- cell surface [IDA, ISO]
- cytoplasm [ISO]
- external side of plasma membrane [IDA]
- extracellular vesicular exosome [ISO]
- focal adhesion [ISO]
- macrophage migration inhibitory factor receptor complex [IDA, ISO]
- nucleus [ISO]
- plasma membrane [IDA, ISO]
- protein complex [ISO]
Mus musculus
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING).
Stimulator of interferon genes (STING) mediates cytosolic DNA-induced innate immune signaling via membrane trafficking. The global identification of proteins that spatiotemporally interact with STING will provide a better understanding of its trafficking mechanisms and of STING signaling pathways. Proximity-dependent biotin identification (BioID) is a powerful technology to identify physiologically relevant protein-protein interactions in living cells. However, biotinylated peptides are rarely ... [more]
J Biol Chem Dec. 07, 2019; 295(32);11174-11183 [Pubmed: 32554809]
Throughput
- High Throughput
Additional Notes
- TurboID fused-STING, peptides were filtered at a false discovery rate (FDR) of 1%.
Curated By
- BioGRID