BAIT
TMEM173
2610307O08Rik, ERIS, MPYS, Mita, STING
transmembrane protein 173
GO Process (11)
GO Function (8)
GO Component (6)
Gene Ontology Biological Process
- activation of innate immune response [IMP, ISO]
- cellular response to exogenous dsRNA [ISO]
- cellular response to interferon-beta [IMP]
- defense response to virus [IMP, ISO]
- innate immune response [IMP, ISO]
- interferon-beta production [IMP, ISO]
- positive regulation of defense response to virus by host [ISO]
- positive regulation of protein binding [ISO]
- positive regulation of protein import into nucleus, translocation [ISO]
- positive regulation of transcription factor import into nucleus [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IDA, ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
SCRIB
AI118201, CRIB, Crc, SCRIB1, Scrb1, mKIAA0147, vartul
scribbled homolog (Drosophila)
GO Process (22)
GO Function (1)
GO Component (13)
Gene Ontology Biological Process
- activation of Rac GTPase activity [ISO]
- apoptotic process involved in morphogenesis [ISO]
- astrocyte cell migration [ISO]
- asymmetric protein localization [IMP]
- auditory receptor cell morphogenesis [IGI]
- auditory receptor cell stereocilium organization [IGI]
- cell migration [IMP, ISO]
- cell proliferation [ISO]
- cochlear nucleus development [IGI]
- establishment of apical/basal cell polarity [ISO]
- mammary gland duct morphogenesis [IMP]
- morphogenesis of embryonic epithelium [IMP]
- negative regulation of mitotic cell cycle [ISO]
- neural tube closure [IMP, ISO]
- positive chemotaxis [IMP, ISO]
- positive regulation of apoptotic process [ISO]
- positive regulation of receptor recycling [ISO]
- protein localization to adherens junction [ISO]
- single organismal cell-cell adhesion [ISO]
- synaptic vesicle endocytosis [IMP]
- synaptic vesicle targeting [IMP]
- wound healing [IGI]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Scrib-APC-beta-catenin complex [ISO]
- basolateral plasma membrane [IDA]
- cell [IMP]
- cell leading edge [ISO]
- cell-cell adherens junction [ISO]
- cell-cell junction [ISO]
- cytoplasm [ISO]
- extracellular vesicular exosome [ISO]
- myelin sheath abaxonal region [IDA]
- nucleoplasm [ISO]
- plasma membrane [ISO]
- postsynaptic membrane [ISO]
- presynaptic membrane [ISO]
Mus musculus
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING).
Stimulator of interferon genes (STING) mediates cytosolic DNA-induced innate immune signaling via membrane trafficking. The global identification of proteins that spatiotemporally interact with STING will provide a better understanding of its trafficking mechanisms and of STING signaling pathways. Proximity-dependent biotin identification (BioID) is a powerful technology to identify physiologically relevant protein-protein interactions in living cells. However, biotinylated peptides are rarely ... [more]
J Biol Chem Dec. 07, 2019; 295(32);11174-11183 [Pubmed: 32554809]
Throughput
- High Throughput
Additional Notes
- TurboID fused-STING, peptides were filtered at a false discovery rate (FDR) of 1%.
Curated By
- BioGRID